streptomycin – streptomycin

Name
WID streptomycin View in model
Name streptomycin View in model
Cross references ChEBI: 17076, PubChem: 46506845, CAS: 57-92-1, KEGG: C00413
 
Classification
Type antibiotic_aminoglycoside View in model
 
Structure
Empirical formula (pH 7.5) H39C21N7O12
SMILES (pH 7.5) CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]2NC(N)=N)O[C@@H](C)[C@]1(O)C=O
Charge (pH 7.5) 0
Is hydrophobic False View in model
Molecular weight (Da) 581.57 View in model
ΔfG'o (pH 7.5, 25C, I = 0; kJ mol‑1) 282.90
 
Comments
Comments Irreversibly binds 30S ribosomal subunit and 16S rRNA. Interferes with decoding site and initiation leading to mRNA misreading [PUB_0847].
References

  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39, D1035-41 (2011). WholeCell: PUB_0847, PubMed: 21059682
 
Metadata
Created 2012-10-01 15:07:07
Last updated 2012-10-01 15:12:32