norfloxacin – Norfloxacin

Name
WID norfloxacin View in model
Name Norfloxacin View in model
Traditional name norfloxacin
IUPAC name 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
Cross references ChEBI: 100246, PubChem: 85306349, KEGG: C06687
 
Classification
Type antibiotic_fluoroquinolone View in model
 
Structure
Empirical formula (pH 7.5) H18C16N3O3F1
SMILES (pH 7.5) CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
Charge (pH 7.5) 0
Is hydrophobic False View in model
Molecular weight (Da) 319.33 View in model
van der Waals volume 
(pH 7.5; Å3 molecule‑1)		 277.46
ΔfG'o (pH 7.5, 25C, I = 0; kJ mol‑1) 617.40
pI 7.38
logP -1.48
logD (pH 7.5) -1.48
 
Function
Reaction participant drug efflux (norfloxacin) via sodium antiport
NA[e] + norfloxacin[c] ⇒ NA[c] + norfloxacin[e]		 View in model
 
Comments
Comments Inhibits topoisomerase II/DNA gyrase and topoisomerase IV [PUB_0847].
References

  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39, D1035-41 (2011). WholeCell: PUB_0847, PubMed: 21059682
 
Metadata
Created 2012-10-01 15:07:04
Last updated 2012-10-01 15:12:24