lomefloxacin – Lomefloxacin

Name
WID lomefloxacin View in model
Name Lomefloxacin View in model
Traditional name lomefloxacin
IUPAC name 1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Cross references ChEBI: 116278, PubChem: 9289, KEGG: C07078
 
Classification
Type antibiotic_fluoroquinolone View in model
 
Structure
Empirical formula (pH 7.5) H19C17N3O3F2
SMILES (pH 7.5) CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
Charge (pH 7.5) 0
Is hydrophobic False View in model
Molecular weight (Da) 351.35 View in model
van der Waals volume 
(pH 7.5; Å3 molecule‑1)		 299.39
ΔfG'o (pH 7.5, 25C, I = 0; kJ mol‑1) 493.50
pI 7.32
logP -1.06
logD (pH 7.5) -1.06
 
Function
Reaction participant drug efflux (lomefloxacin) via sodium antiport
lomefloxacin[c] + NA[e] ⇒ lomefloxacin[e] + NA[c]		 View in model
 
Comments
Comments Inhibits topoisomerase II/DNA gyrase and topoisomerase IV [PUB_0847].
References

  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39, D1035-41 (2011). WholeCell: PUB_0847, PubMed: 21059682
 
Metadata
Created 2012-10-01 15:07:01
Last updated 2012-10-01 15:12:18