erythromycin – erythromycin

Name
WID erythromycin View in model
Name erythromycin View in model
Cross references CAS: 114-07-8, PubChem: 46508487, ChEBI: 48923, KEGG: C01912
 
Classification
Type antibiotic_macrolide View in model
 
Structure
Empirical formula (pH 7.5) H67C37N1O13
SMILES (pH 7.5) CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
Charge (pH 7.5) 0
Is hydrophobic False View in model
Molecular weight (Da) 733.92 View in model
ΔfG'o (pH 7.5, 25C, I = 0; kJ mol‑1) 1365.60
 
Comments
Comments Binds 50 S ribosomal subunit near the P site so that binding of tRNA to the donor site is blocked [PUB_0847]. Also prevents translocation of peptides from the A to P site [PUB_0847].
References

  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39, D1035-41 (2011). WholeCell: PUB_0847, PubMed: 21059682
 
Metadata
Created 2012-10-01 15:06:57
Last updated 2012-10-01 15:12:08