dTpdTp – dTp-dTp

Name
WID	dTpdTp
Name	dTp-dTp
Traditional name	[3-hydroxy-5-(5-methyl-2,4-dioxo-3H-pyrimidin-1-yl)oxolan-2-yl]methyl [5-(5-methyl-2,4-dioxo-3H-pyrimidin-1-yl)-2-[(phosphonatooxy)methyl]oxolan-3-yl] phosphate
IUPAC name	[3-hydroxy-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methyl [5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-2-[(phosphonatooxy)methyl]oxolan-3-yl] phosphate

Classification
Type	dideoxynucleotide

Structure
Empirical formula (pH 7.5)	H₂₅C₂₀N₄O₁₅P₂
SMILES (pH 7.5)	CC1=CN(C2CC(O)C(COP([O-])(=O)OC3CC(OC3COP([O-])([O-])=O)N3C=C(C)C(=O)NC3=O)O2)C(=O)NC1=O
Charge (pH 7.5)	-3
Is hydrophobic	False
Molecular weight (Da)	623.38
van der Waals volume (pH 7.5; Å³ molecule^‑1)	476.00
logP	-1.59
logD (pH 7.5)	-7.32

Function
Reaction participant	DNA resection (dTMP) [c]: dTpdTp + H2O ⇒ (2) DTMP + H deoxyribonuclease (dTMP) [c]: dTpdTp + H2O ⇒ (2) DTMP + H DNA polymerization (dTTP) [c]: DTMP + DTTP ⇒ dTpdTp + PPI DNA cleavage (dTMP) [c]: dTpdTp + H2O ⇒ (2) DTMP + H DNA polymerization (dGTP) [c]: DTMP + DTTP ⇒ dTpdTp + PPI DNA internalization (dTpdTp) (2) dTpdTp[e] + H2O[e] ⇒ (2) DTMP[e] + dTpdTp[c] + H[e]

Metadata
Created	2012-10-01 15:06:55
Last updated	2012-10-01 15:12:05