c_di_AMP – Cyclic-di-adenylate
Name | ||
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WID | c_di_AMP |
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Name | Cyclic-di-adenylate |
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Traditional name | 8,17-bis(6-aminopurin-9-yl)-9,18-dihydroxy-3,12- dioxo-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}- diphosphatricyclo[13.3.0.0^{6,10}]octadecane-3,12- bis(olate) | |
IUPAC name | 8,17-bis(6-amino-9H-purin-9-yl)-9,18-dihydroxy- 3,12-dioxo-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}- diphosphatricyclo[13.3.0.0^{6,10}]octadecane-3,12- bis(olate) | |
Structure | ||
Empirical formula (pH 7.5) | H22C20N10O12P2 | |
SMILES (pH 7.5) | NC1=NC=NC2=C1N=CN2C1OC2COP([O-])(=O)[O-]C3C(COP([O-])(=O)[O-]C2C1O)OC(C3O)N1C=NC2=C1N=CN=C2N | |
Charge (pH 7.5) | -2 | |
Is hydrophobic | False |
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Molecular weight (Da) | 656.40 |
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van der Waals volume (pH 7.5; Å3 molecule‑1) |
479.74 | |
pI | 3.95 | |
logP | -8.10 | |
logD (pH 7.5) | -7.39 | |
Function | ||
Reaction participant | diadenylate cyclase [c]: (2) ATP ⇒ c_di_AMP + (2) PPI |
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Comments | ||
Comments | c-di-AMP may act as second messenger, similar to c-di-GMP to regulate Spo0A [PUB_0512]. c-di-AMP may secreted and trigger a host response [PUB_0683]. Media concentration set to value in Serrano et al M. pneumoniae minimal media [PUB_0614]. | |
References |
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Metadata | ||
Created | 2012-10-01 15:06:51 | |
Last updated | 2012-10-01 15:11:56 |