URI – uridine

Name
WID	URI
Name	uridine
Traditional name	uridine
IUPAC name	1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
Cross references	ChEBI: 16704, PubChem: 3593, CAS: 58-96-8, ThreeDMET: B01210, KNApSAcK: C00019674, ... 4 more

Classification
Type	ribonucleoside

Structure
Empirical formula (pH 7.5)	H₁₂C₉N₂O₆
SMILES (pH 7.5)	OCC1OC(C(O)C1O)N1C=CC(=O)NC1=O
Charge (pH 7.5)	0
Is hydrophobic	False
Molecular weight (Da)	244.20
van der Waals volume (pH 7.5; Å³ molecule^‑1)	197.81
Δ_fG^'o (pH 7.5, 25C, I = 0; kJ mol^‑1)	-203.00
pI	3.42
logP	-2.42
logD (pH 7.5)	-2.42

Function
Reaction participant	uridine kinase (GTP:Uridine) [c]: GTP + URI ⇒ GDP + H + UMP cytidine deaminase [c]: CYTD + H2O ⇒ NH3 + URI pyrimidine-nucleoside phosphorylase (uracil) [c]: (2) H + PI + URI ⇔ R1P + URA

Comments
Comments	Set to value in Serrano et al M. pneumoniae minimal media [PUB_0614].
References	Yus E, Maier T, Michalodimitrakis K, van Noort V, Yamada T, Chen WH, Wodke JA, Güell M, Martínez S, Bourgeois R, Kühner S, Raineri E, Letunic I, Kalinina OV, Rode M, Herrmann R, Gutiérrez-Gallego R, Russell RB, Gavin AC, Bork P, Serrano L. Impact of genome reduction on bacterial metabolism and its regulation. Science 326, 1263-8 (2009). WholeCell: PUB_0614, PubMed: 19965476

Metadata
Created	2012-10-01 15:07:09
Last updated	2012-10-01 15:12:36