URA – uracil

Name
WID	URA
Name	uracil
Traditional name	uracil
IUPAC name	1,2,3,4-tetrahydropyrimidine-2,4-dione
Cross references	ChEBI: 17568, PubChem: 3406, CAS: 66-22-8, ThreeDMET: B00026, KNApSAcK: C00001513, ... 4 more

Classification
Type	nucleobase

Structure
Empirical formula (pH 7.5)	H₄C₄N₂O₂
SMILES (pH 7.5)	O=C1NC=CC(=O)N1
Charge (pH 7.5)	0
Is hydrophobic	False
Molecular weight (Da)	112.09
van der Waals volume (pH 7.5; Å³ molecule^‑1)	88.74
Δ_fG^'o (pH 7.5, 25C, I = 0; kJ mol^‑1)	-39.10
logP	-0.860
logD (pH 7.5)	-0.860

Concentrations
Media composition (SP4; mM)	0.178

Function
Reaction participant	DNA radiation (gamma-ray) induced base oxidation (uracil ==> 5,6-dihydroxyuracil; dialuric acid; hydroxyl radical) gamma_radiation[e] + (2) hydroxyl_radical[c] + URA[c] ⇒ DHURA[c] + (2) H[c] base excision (uracil) [c]: DUMP + H2O ⇒ DR5P + URA uracil phosphoribosyltransferase [c]: PRPP + URA ⇒ PPI + UMP pyrimidine-nucleoside phosphorylase (uracil) [c]: (2) H + PI + URI ⇔ R1P + URA deoxyuridine phosphorylase [c]: DU + PI ⇔ DR1P + URA ... 5 more DNA radiation (gamma-ray) induced base oxidation (uracil ==> 5-hydroxy-6-hydroxyuracil; hydroxyl radical) gamma_radiation[e] + H[c] + hydroxyl_radical[c] + URA[c] ⇒ ho5ho6URA[c] uracil transport via proton symport H[e] + URA[e] ⇔ H[c] + URA[c] DNA radiation (gamma-ray) induced base oxidation (uracil ==> 5-hydroxyuracil; hydroxyl radical) gamma_radiation[e] + hydroxyl_radical[c] + URA[c] ⇒ H[c] + ho5URA[c] purine-nucleoside phosphorylase (Deoxyuridine) [c]: DU + PI ⇔ DR1P + URA Spontaneous base deamination (cytosine ==> uracil) [c]: CSN + H2O ⇒ NH3 + URA

Metadata
Created	2012-10-01 15:07:09
Last updated	2012-10-01 15:12:36