TranscriptionalRegulation_spx_TU_076 – Transcriptional regulation of TU_076 by spx

WID TranscriptionalRegulation_spx_TU_076
Name Transcriptional regulation of TU_076 by spx
Transcription unit TU_076 View in model
Transcripton factor MG_127_MONOMER View in model
Fold‑change activity
14.8472 (dimensionless)
View in model
Comments Spx is activated by thiol-specific oxidative stress, and enhances the expression of reductases [PUB_0434, PUB_0435, PUB_0436]. Spx transcriptional regulatory activity described by several groups [PUB_0112, PUB_0420, PUB_0434, PUB_0435, PUB_0436, PUB_0437]. Doesn't directly interact with DNA. Effects transcription rates by interacting only with RNA polymerase [PUB_0434]. Site responds to the condition: thiol stress (1 mM l-cysteine, l-methionine, MgSO4, or diamide).
  1. Choi SY, Reyes D, Leelakriangsak M, Zuber P. The global regulator Spx functions in the control of organosulfur metabolism in Bacillus subtilis. J Bacteriol 188, 5741-51 (2006). WholeCell: PUB_0436, PubMed: 16885442

  2. Erwin KN, Nakano S, Zuber P. Sulfate-dependent repression of genes that function in organosulfur metabolism in Bacillus subtilis requires Spx. J Bacteriol 187, 4042-9 (2005). WholeCell: PUB_0435, PubMed: 15937167

  3. Nakano MM, Lin A, Zuber CS, Newberry KJ, Brennan RG, Zuber P. Promoter recognition by a complex of Spx and the C-terminal domain of the RNA polymerase alpha subunit. PLoS One 5, e8664 (2010). WholeCell: PUB_0420, PubMed: 20084284

  4. Nakano S, Küster-Schöck E, Grossman AD, Zuber P. Spx-dependent global transcriptional control is induced by thiol-specific oxidative stress in Bacillus subtilis. Proc Natl Acad Sci U S A 100, 13603-8 (2003). WholeCell: PUB_0434, PubMed: 14597697

  5. Newberry KJ, Nakano S, Zuber P, Brennan RG. Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase. Proc Natl Acad Sci U S A 102, 15839-44 (2005). WholeCell: PUB_0112, PubMed: 16249335

  6. Pamp SJ, Frees D, Engelmann S, Hecker M, Ingmer H. Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococcus aureus. J Bacteriol 188, 4861-70 (2006). WholeCell: PUB_0437, PubMed: 16788195

Created 2012-10-01 15:09:29
Last updated 2012-10-01 15:18:57