TranscriptionalRegulation_fur_TU_008 – Transcriptional regulation of TU_008 by fur

WID TranscriptionalRegulation_fur_TU_008
Name Transcriptional regulation of TU_008 by fur
Transcription unit TU_008 View in model
Transcripton factor MG_236_MONOMER View in model
Binding site 1504116054 MG471 MG472 MG_013 MG_014
Chromosome: Mgenitalium_Chr_1, Coordinate: 15541 (nt), Length: 13 (nt), Direction: Forward, Sequence:
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10.0 (nM)
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Fold‑change activity
0.2 (dimensionless)
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Comments Fur transcription factor is activated by iron stress (low iron or iron deficiency), and negatively regulates expression of siderophore biosynthesis and ferri-siderophore uptake genes [PUB_0418, PUB_0419, PUB_0438]. Fur transcriptional regulatory activity inferred from B. subtilis [PUB_0438 table 2, PUB_0419]. Binding site computed by aligning upstream regions (100bp) using MEME. Guell et al used the same procedure for M. pneumoniae, but identified a different motif [PUB_0418]. Binding site has motif TGA[TA]AAT[GC]ATT[AT]TCA[AT]T. Site responds to the condition: 0.1 um FeCl3.
  1. Baichoo N, Wang T, Ye R, Helmann JD. Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Mol Microbiol 45, 1613-29 (2002). WholeCell: PUB_0438, PubMed: 12354229

  2. Güell M, van Noort V, Yus E, Chen WH, Leigh-Bell J, Michalodimitrakis K, Yamada T, Arumugam M, Doerks T, Kühner S, Rode M, Suyama M, Schmidt S, Gavin AC, Bork P, Serrano L. Transcriptome complexity in a genome-reduced bacterium. Science 326, 1268-71 (2009). WholeCell: PUB_0418, PubMed: 19965477

  3. Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic Acids Res 36, D93-6 (2008). WholeCell: PUB_0419, PubMed: 17962296, URL:

Created 2012-10-01 15:09:28
Last updated 2012-10-01 15:18:56