ThyA – thymidylate synthase
Name | ||
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WID | ThyA |
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Name | thymidylate synthase |
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Cross references | EC: 2.1.1.45, SABIO-RK: 5048, KEGG: R02101, BioCyc: THYMIDYLATESYN-RXN, BiGG: TMDS | |
Classification | ||
Type | chemical |
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Reaction | ||
Stoichiometry | [c]: DUMP + METTHF ⇒ DHF + DTMP + (2) H |
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Catalysis | ||
Enzyme | MG_227_DIMER [c] |
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Optimal pH | 7.1 (dimensionless) |
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Optimal temperature | 38.0 (C) |
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Energetics | ||
Is spontaneous (pH 7.5, 25C, I = 0) | False |
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ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) | -16.00 | |
Keq | 3.47969349105e+11 () |
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Kinetics | ||
Forward kinetics | v = Vmax * [DUMP] * [METTHF] / (Km1 * Km2 + Km1 * [METTHF] + Km2 * [DUMP]); Km1 = 2.7 (nM), Km2 = 10.1 (nM), Vmax = 12.78 1/min (Show evidence) |
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Associations | ||
Pathways | NUCLEOTIDE_SALVAGE_PWY | |
Process | Process_Metabolism |
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Comments | ||
References |
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Metadata | ||
Created | 2012-10-01 15:09:02 | |
Last updated | 2012-10-01 15:17:54 |