ThyA – thymidylate synthase

Name
WID ThyA View in model
Name thymidylate synthase View in model
Cross references EC: 2.1.1.45, SABIO-RK: 5048, KEGG: R02101, BioCyc: THYMIDYLATESYN-RXN, BiGG: TMDS
 
Classification
Type chemical View in model
 
Reaction
Stoichiometry [c]: DUMP + METTHF ⇒ DHF + DTMP + (2) H View in model
 
Catalysis
Enzyme MG_227_DIMER [c] View in model
Optimal pH
7.1 (dimensionless)
Optimal temperature
38.0 (C)
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) -16.00
Keq
3.47969349105e+11 ()
 
Kinetics
Forward kinetics
v = Vmax * [DUMP] * [METTHF] / (Km1 * Km2 + Km1 * [METTHF] + Km2 * [DUMP]); Km1 = 2.7 (nM), Km2 = 10.1 (nM), Vmax = 12.78 1/min (Show evidence)
 View in model
 
Associations
Pathways NUCLEOTIDE_SALVAGE_PWY
Process Process_Metabolism View in model
 
Comments
References

  1. Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/
 
Metadata
Created 2012-10-01 15:09:02
Last updated 2012-10-01 15:17:54