Tdk1 – deoxyuridine kinase (ATP:Deoxyuridine)

Name
WID	Tdk1
Name	deoxyuridine kinase (ATP:Deoxyuridine)
Cross references	EC: 2.7.1.21, BioCyc: DURIDKI-RXN, BiGG: DURIK1, KEGG: R02099

Classification
Type	chemical

Reaction
Stoichiometry	[c]: ATP + DU ⇒ ADP + DUMP + H

Catalysis
Enzyme	MG_034_DIMER [c]
Optimal pH	7.8 (dimensionless)
Optimal temperature	31.0 (C)

Energetics
Is spontaneous (pH 7.5, 25C, I = 0)	False
ΔG (pH 7.5, 25C, I = 0; kJ mol^‑1)	-3.80
K_eq	550.954774449 ()

Kinetics
Forward kinetics	v = V_max * [DU] / (K_m + [DU]); K_m = 2.5 (nM), V_max = 4.35 U/mg (Show evidence) Value: Rate law: VmaxDU/(Km+DU); Km = 0.0047 mM, Vmax = 0.0047 umol/(minmg) (None) Measured: Yes Species: Herpes simplex References Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/

Associations
Pathways	NUCLEOTIDE_SALVAGE_PWY
Process	Process_Metabolism

Comments
Comments	Kinetics set to that of Tdk2.
References	Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/

Metadata
Created	2012-10-01 15:09:02
Last updated	2012-10-01 15:17:54