RelA1 – GDP diphosphokinase

WID RelA1 View in model
Name GDP diphosphokinase View in model
Cross references EC:, BiGG: GDPDPK, BioCyc: GDPPYPHOSKIN-RXN
Type chemical View in model
Stoichiometry [c]: ATP + GDPAMP + H + PPGPP View in model
Enzyme MG_278_DIMER [c] View in model
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) -3.80
550.954774449 ()
Process Process_Metabolism View in model
Comments produces (p)ppGpp under starvation conditions (stringent response) [PUB_0149]; ppGpp in turn regulates transcription of rRNA and tRNA, translation, and replication [PUB_0149]; ACP interacts with spoT to shift equlibrium toward (p)ppGpp and away from GTP/GDP and pyrophosphate [PUB_0149]; ribosome-associated (p)ppGpp synthetase responding mainly to uncharged tRNAs that accumulate and binds to ribosomes A-site as a result of amino acid limitation [PUB_0150]; recognizes stalled ribosomes and synthesizes ppGpp [PUB_0153]; ppGpp binds in the secondary channel of RNA polymerase and prevents transcription of tRNA, rRNA [PUB_0151]; ppGpp promotes transcription of amino acid biosynthesis genes [PUB_0151]; ppGpp inhibits DNA primase [PUB_0152]; Mn2+ cofactor requirement inferred by homology [PUB_0096].
  1. Braeken K, Moris M, Daniels R, Vanderleyden J, Michiels J. New horizons for (p)ppGpp in bacterial and plant physiology. Trends Microbiol 14, 45-54 (2006). WholeCell: PUB_0150, PubMed: 16343907

  2. Jain V, Kumar M, Chatterji D. ppGpp: stringent response and survival. J Microbiol 44, 1-10 (2006). WholeCell: PUB_0153, PubMed: 16554711

  3. Potrykus K, Cashel M. (p)ppGpp: still magical?. Annu Rev Microbiol 62, 35-51 (2008). WholeCell: PUB_0152, PubMed: 18454629

  4. Srivatsan A, Wang JD. Control of bacterial transcription, translation and replication by (p)ppGpp. Curr Opin Microbiol 11, 100-5 (2008). WholeCell: PUB_0149, PubMed: 18359660

  5. Traxler MF, Summers SM, Nguyen HT, Zacharia VM, Hightower GA, Smith JT, Conway T. The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli. Mol Microbiol 68, 1128-48 (2008). WholeCell: PUB_0151, PubMed: 18430135

  6. UniProt Consortium. The Universal Protein Resource (UniProt) 2009. Nucleic Acids Res 37, D169-74 (2009). WholeCell: PUB_0096, PubMed: 18836194, URL:

Created 2012-10-01 15:09:00
Last updated 2012-10-01 15:17:48