Process_ProteinProcessingII – Protein processing II

WID Process_ProteinProcessingII
Name Protein processing II
Initialization order 20 View in model
Chemical reactions prolipoprotein diacylglyceryl transferase
CYS[c] + PG160[m] ⇒ diacylglycerolCys[c] + H[c] + SNGLYP[c]
View in model
  • Parameter_0104: lipoproteinDiacylglycerylTransferaseSpecificRate = 0.0165 1/s

  • Parameter_0105: lipoproteinSignalPeptidaseSpecificRate = 11 1/s

View in model
Comments Simulates maturation of lipoproteins: diacylglyceryl transfer – Lgt (MG_086) catalyzes transfer of diacylglycerol group to sulfhydryl group of lipobox cysteine [PUB_0654] signal peptide cleavage – LspA (MG_210) cleaves lipoprotein at lipobox cysteine [PUB_0654] Note M. genitalium does contain a apolipoprotein transacylase [PUB_0655, PUB_0656, PUB_0657]. Lipoproteins participate in many processes including: Nutrient acquisition Adaptation Protein maturation Adherence Virulence Conjugation Sporulation Transport Signal transduction References PUB_0654 PUB_0655 PUB_0656 PUB_0657 PUB_0658
  1. Chambaud I, Heilig R, Ferris S, Barbe V, Samson D, Galisson F, Moszer I, Dybvig K, Wróblewski H, Viari A, Rocha EP, Blanchard A. The complete genome sequence of the murine respiratory pathogen Mycoplasma pulmonis. Nucleic Acids Res 29, 2145-53 (2001). WholeCell: PUB_0655, PubMed: 11353084

  2. Chambaud I, Wróblewski H, Blanchard A. Interactions between mycoplasma lipoproteins and the host immune system. Trends Microbiol 7, 493-9 (1999). WholeCell: PUB_0654, PubMed: 10603485

  3. Mühlradt PF, Kiess M, Meyer H, Süssmuth R, Jung G. Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J Exp Med 185, 1951-8 (1997). WholeCell: PUB_0656, PubMed: 9166424

  4. Piec G, Mirkovitch J, Palacio S, Mühlradt PF, Felix R. Effect of MALP-2, a lipopeptide from Mycoplasma fermentans, on bone resorption in vitro. Infect Immun 67, 6281-5 (1999). WholeCell: PUB_0657, PubMed: 10569738

  5. Smith PF. Lipoglycans from mycoplasmas. Crit Rev Microbiol 11, 157-86 (1984). WholeCell: PUB_0658, PubMed: 6375975

Created 2012-10-01 15:07:35
Last updated 2012-10-01 15:14:00