Parameter_0157 – meanNDPConcentration

WID Parameter_0157
Name meanNDPConcentration
Synonyms Mean NDP concentration
0.5 (mM) (Show evidence)
View in model
State State_Metabolite
Comments Bennett et al report the intracellular ADP of E. coli is 0.560 mM [PUB_0859]. Albe et al report the intracellular ADP concentration is 0.823 mM [PUB_0860]. We initialize ADP and GDP to a comparable concentration of 0.5 mM. Our model does not capture the intracellular concentrations of CDP and UDP well, and are therefore initialized to 0 mM.
  1. Albe KR, Butler MH, Wright BE. Cellular concentrations of enzymes and their substrates. J Theor Biol 22143, 163-95 (1990). WholeCell: PUB_0860, PubMed: 2200929

  2. Bennett BD, Kimball EH, Gao M, Osterhout R, Van Dien SJ, Rabinowitz JD. Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat Chem Biol 5, 593-9 (2009). WholeCell: PUB_0859, PubMed: 19561621

Created 2012-10-01 15:09:28
Last updated 2012-10-01 15:18:56