Parameter_0156 – meanNTPConcentration

WID Parameter_0156
Name meanNTPConcentration
Synonyms Mean NTP concentration
5 (mM) (Show evidence)
View in model
State State_Metabolite
Comments Bennett et al report the intracellular ATP, CTP, GTP and UTP concentrations of E. coli are 9.6, 1.2, 4.9, and 8.3 mM [PUB_0859]. Albe et al report the intracellular ATP concentration is 2.6 mM [PUB_0860]. We initialize ATP and GTP to a comparable concentration of 5 mM. Our model does not capture the intracellular concentrations of CTP and UTP well, and are therefore initialized to 0 mM.
  1. Albe KR, Butler MH, Wright BE. Cellular concentrations of enzymes and their substrates. J Theor Biol 22143, 163-95 (1990). WholeCell: PUB_0860, PubMed: 2200929

  2. Bennett BD, Kimball EH, Gao M, Osterhout R, Van Dien SJ, Rabinowitz JD. Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat Chem Biol 5, 593-9 (2009). WholeCell: PUB_0859, PubMed: 19561621

Created 2012-10-01 15:09:28
Last updated 2012-10-01 15:18:56