PRPP – 5-Phospho-alpha-D-ribose 1-diphosphate

Name
WID	PRPP
Name	5-Phospho-alpha-D-ribose 1-diphosphate
Traditional name	{3,4-dihydroxy-5-[(phosphonatooxy)methyl]oxolan-2-yl} (phosphonatooxy)phosphonate
IUPAC name	{3,4-dihydroxy-5-[(phosphonatooxy)methyl]oxolan-2-yl} (phosphonatooxy)phosphonate
Cross references	ChEBI: 17111, PubChem: 3419, ThreeDMET: B01164, KNApSAcK: C00007296, KEGG: C00119, ... 3 morePDBCCD: PRP, BioCyc: PRPP, BiGG: prpp

Classification
Type	carbohydrate_sugar_phosphate

Structure
Empirical formula (pH 7.5)	H₈C₅O₁₄P₃
SMILES (pH 7.5)	OC1C(O)C(OP([O-])(=O)OP([O-])([O-])=O)OC1COP([O-])([O-])=O
Charge (pH 7.5)	-5
Is hydrophobic	False
Molecular weight (Da)	385.03
van der Waals volume (pH 7.5; Å³ molecule^‑1)	250.91
Δ_fG^'o (pH 7.5, 25C, I = 0; kJ mol^‑1)	-2977.90
logP	-2.97
logD (pH 7.5)	-11.29

Function
Reaction participant	hypoxanthine phosphoribosyltransferase (Hypoxanthine) [c]: HYXN + PRPP ⇒ IMP + PPI uracil phosphoribosyltransferase [c]: PRPP + URA ⇒ PPI + UMP guanine phosphoribosyltransferase [c]: GN + PRPP ⇒ GMP + PPI nicotinic acid mononucleotide pyrophosphorylase [c]: ATP + (3) H + H2O + NAC + PRPP ⇒ ADP + NAMN + PI + PPI adenine phosphoribosyltransferase [c]: AD + PRPP ⇒ AMP + PPI phosphoribosylpyrophosphate synthetase [c]: ATP + R5P ⇔ AMP + H + PRPP

Metadata
Created	2012-10-01 15:07:06
Last updated	2012-10-01 15:12:29