PPI – diphosphate

Name
WID	PPI
Name	diphosphate
Traditional name	diphosphate(3-)
IUPAC name	(hydrogen phosphonatooxy)phosphonate
Cross references	ChEBI: 18361, CAS: 2466-09-3, PubChem: 3315, ThreeDMET: B00003, KEGG: C00013, ... 4 more

Classification
Type	ion

Structure
Empirical formula (pH 7.5)	H₁O₇P₂
SMILES (pH 7.5)	OP([O-])(=O)OP([O-])([O-])=O
Charge (pH 7.5)	-3
Is hydrophobic	False
Molecular weight (Da)	174.95
van der Waals volume (pH 7.5; Å³ molecule^‑1)	101.91
Δ_fG^'o (pH 7.5, 25C, I = 0; kJ mol^‑1)	-1939.20
logP	-1.44
logD (pH 7.5)	-6.65

Function
Complex subunit	Dodecanoyl-ACP (n-C12:0ACP) [c]: ATP + COA + DDCA + MG_287_MONOMER ⇒ AMP + H + PAP + PPI + MG_287_MONOMER_ddcaACP cis-hexadec-9-enoyl-[acyl-carrier protein] (n-C16:1) [c]: ATP + COA + HDCEA + MG_287_MONOMER ⇒ AMP + H + PAP + PPI + MG_287_MONOMER_hdeACP Myristoyl-ACP (n-C14:0ACP) [c]: ATP + COA + MG_287_MONOMER + TTDCA ⇒ AMP + H + PAP + PPI + MG_287_MONOMER_myrsACP Octadecanoyl-ACP (n-C18:0ACP) [c]: ATP + COA + MG_287_MONOMER + OCDCA ⇒ AMP + H + PAP + PPI + MG_287_MONOMER_ocdcaACP cis-octadec-11-enoyl-[acyl-carrier protein] (n-C18:1) [c]: ATP + COA + MG_287_MONOMER + OCDCEA ⇒ AMP + H + PAP + PPI + MG_287_MONOMER_octeACP ... 2 more Palmitoyl-ACP (n-C16:0ACP) [c]: ATP + COA + HDCA + MG_287_MONOMER ⇒ AMP + H + PAP + PPI + MG_287_MONOMER_palmACP cis-tetradec-7-enoyl-[acyl-carrier protein] (n-C14:1) [c]: ATP + COA + MG_287_MONOMER + TTDCEA ⇒ AMP + H + PAP + PPI + MG_287_MONOMER_tdeACP
Reaction participant	DNA polymerization (dGTP) [c]: DGMP + DGTP ⇒ dGpdGp + PPI acyl-[acyl-carrier-protein] synthetase (n-C16:1) [c]: ATP + HDCEA + MG_287_MONOMER_ACP ⇒ AMP + MG_287_MONOMER_hdeACP + PPI methionyl-tRNA (MG485) aminoacylation [c]: ATP + MET ⇒ AMP + PPI adenine phosphoribosyltransferase [c]: AD + PRPP ⇒ AMP + PPI leucyl-tRNA (MG520) aminoacylation [c]: ATP + LEU ⇒ AMP + PPI ... 117 more tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER nicotinamide-nucleotide adenylyltransferase [c]: ATP + H + NMN ⇒ NAD + PPI CDP-diacylglycerol synthetase (n-C12:0) CTP[c] + H[c] + PA120[m] ⇔ CDPDG120[m] + PPI[c] tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER acyl-[acyl-carrier-protein] synthetase (n-C16:0) [c]: ATP + HDCA + MG_287_MONOMER_ACP ⇒ AMP + MG_287_MONOMER_palmACP + PPI DNA primer polymerization (GTP) [c]: GMP + GTP ⇒ GpGp + PPI FMN adenylyltransferase [c]: ATP + FMN + H ⇒ FAD + PPI lysyl-tRNA (MG501) aminoacylation [c]: ATP + LYS ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER alanyl-tRNA (MG471) aminoacylation [c]: ALA + ATP ⇒ AMP + PPI DNA polymerization (dGTP) [c]: DGMP + DGTP ⇒ dGpdGp + PPI RNA polymerization (UTP) [c]: UMP + UTP ⇒ PPI + UpUp tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER CDP-diacylglycerol synthetase (n-C18:0) CTP[c] + H[c] + PA180[m] ⇔ CDPDG180[m] + PPI[c] leucyl-tRNA (MG500) aminoacylation [c]: ATP + LEU ⇒ AMP + PPI tRNA U34 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s2UMP + SER tryptophanyl-tRNA (MG496) aminoacylation [c]: ATP + TRP ⇒ AMP + PPI DNA primer polymerization (UTP) [c]: UMP + UTP ⇒ PPI + UpUp leucyl-tRNA (MG519) aminoacylation [c]: ATP + LEU ⇒ AMP + PPI glycyl-tRNA (MG493) aminoacylation [c]: ATP + GLY ⇒ AMP + PPI CDP-diacylglycerol synthetase (n-C16:1) CTP[c] + H[c] + PA161[m] ⇔ CDPDG161[m] + PPI[c] asparaginyl-tRNA (MG514) aminoacylation [c]: ASN + ATP ⇒ AMP + PPI Nicotinate-mononucleotide adenylyltransferase [c]: ATP + H + NMN ⇒ NAD + PPI seryl-tRNA (MG507) aminoacylation [c]: ATP + SER ⇒ AMP + PPI hypoxanthine phosphoribosyltransferase (Hypoxanthine) [c]: HYXN + PRPP ⇒ IMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER valyl-tRNA (MG511) aminoacylation [c]: ATP + VAL ⇒ AMP + PPI CDP-diacylglycerol synthetase (n-C14:1) CTP[c] + H[c] + PA141[m] ⇔ CDPDG141[m] + PPI[c] CDP-diacylglycerol synthetase (n-C14:0) CTP[c] + H[c] + PA140[m] ⇔ CDPDG140[m] + PPI[c] tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER acyl-[acyl-carrier-protein] synthetase (n-C12:0) [c]: ATP + DDCA + MG_287_MONOMER_ACP ⇒ AMP + MG_287_MONOMER_ddcaACP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER lysyl-tRNA (MG509) aminoacylation [c]: ATP + LYS ⇒ AMP + PPI tRNA(Ile)-lysidine synthetase [c]: ATP + CMP + LYS ⇒ AMP + (2) H + k2CMP + PPI aspartyl-tRNA (MG489) aminoacylation [c]: ASP + ATP ⇒ AMP + PPI isoleucyl-tRNA (MG472) aminoacylation [c]: ATP + ILE ⇒ AMP + PPI DNA polymerization (dACP) [c]: DCMP + DCTP ⇒ dCpdCp + PPI tmRNA (MG_0004) aminoacylation [c]: ALA + ATP ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER arginyl-tRNA (MG495) aminoacylation [c]: ARG + ATP ⇒ AMP + PPI tRNA U34 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s2UMP + SER DNA primer polymerization (CTP) [c]: CMP + CTP ⇒ CpCp + PPI DNA polymerization (dCTP) [c]: DCMP + DCTP ⇒ dCpdCp + PPI methionine adenosyltransferase [c]: ATP + H2O + MET ⇒ AMET + PI + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tryptophanyl-tRNA (MG504) aminoacylation [c]: ATP + TRP ⇒ AMP + PPI guanine phosphoribosyltransferase [c]: GN + PRPP ⇒ GMP + PPI RNA polymerization (ATP) [c]: AMP + ATP ⇒ ApAp + PPI seryl-tRNA (MG506) aminoacylation [c]: ATP + SER ⇒ AMP + PPI acyl-[acyl-carrier-protein] synthetase (n-C14:1) [c]: ATP + MG_287_MONOMER_ACP + TTDCEA ⇒ AMP + MG_287_MONOMER_tdeACP + PPI DNA polymerization (dATP) [c]: DAMP + DATP ⇒ dApdAp + PPI DNA polymerization (dATP) [c]: DAMP + DATP ⇒ dApdAp + PPI UTP-glucose-1-phosphate uridylyltransferase (irreversible) [c]: G1P + H + UTP ⇔ PPI + UDPG tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER cysteinyl-tRNA (MG483) aminoacylation [c]: ATP + CYS ⇒ AMP + PPI CDP-diacylglycerol synthetase (n-C18:1) CTP[c] + H[c] + PA181[m] ⇔ CDPDG181[m] + PPI[c] tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER RNA polymerization (CTP) [c]: CMP + CTP ⇒ CpCp + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER seryl-tRNA (MG487) aminoacylation [c]: ATP + SER ⇒ AMP + PPI histidyl-tRNA (MG518) aminoacylation [c]: ATP + HIS ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER acyl-[acyl-carrier-protein] synthetase (n-C14:0) [c]: ATP + MG_287_MONOMER_ACP + TTDCA ⇒ AMP + MG_287_MONOMER_myrsACP + PPI diadenylate cyclase [c]: (2) ATP ⇒ c_di_AMP + (2) PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER uracil phosphoribosyltransferase [c]: PRPP + URA ⇒ PPI + UMP DNA polymerization (dGTP) [c]: DTMP + DTTP ⇒ dTpdTp + PPI glutamy-tRNA (MG502) aminoacylation [c]: ATP + GLU ⇒ AMP + PPI acyl-[acyl-carrier-protein] synthetase (n-C18:1) [c]: ATP + MG_287_MONOMER_ACP + OCDCEA ⇒ AMP + MG_287_MONOMER_octeACP + PPI Nicotinate-mononucleotide adenylyltransferase [c]: ATP + H + NAMN ⇒ NAAD + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER threonyl-tRNA (MG510) aminoacylation [c]: ATP + THR ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER prolyl-tRNA (MG484) aminoacylation [c]: ATP + PRO ⇒ AMP + PPI CDP-diacylglycerol synthetase (n-C16:0) CTP[c] + H[c] + PA160[m] ⇔ CDPDG160[m] + PPI[c] arginyl-tRNA (MG492) aminoacylation [c]: ARG + ATP ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER threonyl-tRNA (MG512) aminoacylation [c]: ATP + THR ⇒ AMP + PPI formyl-methionyl-tRNA (MG488) aminoacylation [c]: ATP + MET ⇒ AMP + PPI seryl-tRNA (MG475) aminoacylation [c]: ATP + SER ⇒ AMP + PPI DNA primer polymerization (ATP) [c]: AMP + ATP ⇒ ApAp + PPI RNA polymerization (GTP) [c]: GMP + GTP ⇒ GpGp + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER arginyl-tRNA (MG497) aminoacylation [c]: ARG + ATP ⇒ AMP + PPI threonyl-tRNA (MG479) aminoacylation [c]: ATP + THR ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER nicotinic acid mononucleotide pyrophosphorylase [c]: ATP + (3) H + H2O + NAC + PRPP ⇒ ADP + NAMN + PI + PPI glutamyl-tRNA (MG513) aminoacylation [c]: ATP + GLU ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER leucyl-tRNA (MG508) aminoacylation [c]: ATP + LEU ⇒ AMP + PPI arginyl-tRNA (MG523) aminoacylation [c]: ARG + ATP ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER acyl-[acyl-carrier-protein] synthetase (n-C18:0) [c]: ATP + MG_287_MONOMER_ACP + OCDCA ⇒ AMP + MG_287_MONOMER_ocdcaACP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER phenylalanyl-tRNA (MG490) aminoacylation [c]: ATP + PHE ⇒ AMP + PPI ATP:lipoate adenylyltransferase [c]: ATP + H + LIPOATE ⇒ LIPOYLAMP + PPI tyrosyl-tRNA (MG503) aminoacylation [c]: ATP + TYR ⇒ AMP + PPI NAD synthase (nh3) [c]: ATP + NAAD + NH3 ⇒ AMP + (3) H + NAD + PPI isoleucyl-tRNA (MG486) aminoacylation [c]: ATP + ILE ⇒ AMP + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER DNA polymerization (dTTP) [c]: DTMP + DTTP ⇒ dTpdTp + PPI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER tRNA U34 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s2UMP + SER inorganic diphosphatase [c]: H2O + PPI ⇒ H + (2) PI tRNA U8 sulfurtransferase [c]: ATP + CYS + H2O + UMP ⇒ AMP + H + PPI + s4UMP + SER glycyl-tRNA (MG499) aminoacylation [c]: ATP + GLY ⇒ AMP + PPI

Metadata
Created	2012-10-01 15:07:06
Last updated	2012-10-01 15:12:29


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