NrdEF_UDP – ribonucleoside-diphosphate reductase (UDP)

Name
WID NrdEF_UDP View in model
Name ribonucleoside-diphosphate reductase (UDP) View in model
Cross references EC: 1.17.4.1, KEGG: R02018, BiGG: RNDR4, BioCyc: UDPREDUCT-RXN
 
Classification
Type chemical View in model
 
Reaction
Stoichiometry [c]: MG_229_231_TETRAMER + O2 + (2) UDP ⇒ (2) DUDP + (2) H2O + MG_229_231_TETRAMER_ox View in model
 
Catalysis
Enzyme MG_229_231_TETRAMER [c] View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
 
Associations
Pathways NUCLEOTIDE_SALVAGE_PWY
Process Process_Metabolism View in model
 
Comments
Comments Oxygen coordinates to Y126 of NrdF (MG_229) C176 and C413 of NrdE (MG_231) reduce NDP, and form disulfide bond References Cotruvo and Stubbe, 2008 [PUB_0160]
References

  1. Cotruvo JA Jr, Stubbe J. NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Proc Natl Acad Sci U S A 105, 14383-8 (2008). WholeCell: PUB_0160, PubMed: 18799738
 
Metadata
Created 2012-10-01 15:08:53
Last updated 2012-10-01 15:17:27