Note_ProteinDegradation – ProteinDegradation

WID Note_ProteinDegradation
Name ProteinDegradation
Comments Under normal growth conditions protein degradation is 1-2.5% 1/h. Under starvation conditions this increases to 4-5%. Protein degradation is mediated by two processive proteases Lon and FtsH, and several peptidases [PUB_0029, PUB_0030, PUB_0031].
  1. Bruckner RC, Gunyuzlu PL, Stein RL. Coupled kinetics of ATP and peptide hydrolysis by Escherichia coli FtsH protease. Biochemistry 42, 10843-52 (2003). WholeCell: PUB_0031, PubMed: 12962509

  2. Ito K, Akiyama Y. Cellular functions, mechanism of action, and regulation of FtsH protease. Annu Rev Microbiol 59, 211-31 (2005). WholeCell: PUB_0030, PubMed: 15910274

  3. Lee I, Suzuki CK. Functional mechanics of the ATP-dependent Lon protease- lessons from endogenous protein and synthetic peptide substrates. Biochim Biophys Acta 1784, 727-35 (2008). WholeCell: PUB_0029, PubMed: 18359303

Created 2012-10-01 15:07:34
Last updated 2012-10-01 15:13:58