NU – nitrosourea

Name
WID	NU
Name	nitrosourea
Traditional name	nitrosourea
IUPAC name	nitrosourea
Cross references	PubChem: 10233735, CAS: 13010-20-3

Classification
Type	alkylating_byproduct_methylation

Structure
Empirical formula (pH 7.5)	H₃C₁N₃O₂
SMILES (pH 7.5)	C(=O)(N)NN=O
Charge (pH 7.5)	0
Is hydrophobic	False
Molecular weight (Da)	89.05
van der Waals volume (pH 7.5; Å³ molecule^‑1)	67.35
pI	2.29
logP	-0.750
logD (pH 7.5)	-0.760

Function
Reaction participant	DNA base methylation (adenine ==> 3-methyladenine; N-methyl-N-nitrosourea) [c]: AD + MNU ⇒ m3AD + NU DNA base ethylation (adenine ==> 7-ethyladenine; ethyl nitrosourea) [c]: AD + ENU ⇒ e7AD + NU DNA base methylation (thymine ==> 2'-O-methylthymine; N-methyl-N-nitrosourea) [c]: MNU + THY ⇒ NU + O2mTHY DNA base methylation (thymine ==> 4'-O-methylthymine; N-methyl-N-nitrosourea) [c]: MNU + THY ⇒ NU + O4mTHY DNA base ethylation (guanine ==> 3-ethylguanine; ethyl nitrosourea) [c]: ENU + GN ⇒ e3GN + NU ... 20 more DNA base methylation (guanine ==> 6'-O-methylguanine; N-methyl-N-nitrosourea) [c]: GN + MNU ⇒ NU + O6mGN DNA base ethylation (adenine ==> 1-ethyladenine; ethyl nitrosourea) [c]: AD + ENU + H ⇒ e1AD + NU DNA base methylation (guanine ==> 3-methylguanine; N-methyl-N-nitrosourea) [c]: GN + MNU ⇒ m3GN + NU DNA base ethylation (adenine ==> 6-ethyladenine; ethyl nitrosourea) [c]: AD + ENU ⇒ e6AD + NU DNA base ethylation (guanine ==> 1-ethylguanine; ethyl nitrosourea) [c]: ENU + GN ⇒ e1GN + NU DNA base ethylation (thymine ==> 3'-ethylthymine; ethyl nitrosourea) [c]: ENU + THY ⇒ e3THY + NU DNA base methylation (guanine ==> 7-methylguanine; N-methyl-N-nitrosourea) [c]: GN + H + MNU ⇒ m7GN + NU DNA base ethylation (adenine ==> 3-ethyladenine; ethyl nitrosourea) [c]: AD + ENU ⇒ e3AD + NU DNA base methylation (adenine ==> 7-methyladenine; N-methyl-N-nitrosourea) [c]: AD + MNU ⇒ m7AD + NU DNA base methylation (guanine ==> 1-methylguanine; N-methyl-N-nitrosourea) [c]: GN + MNU ⇒ m1GN + NU DNA base methylation (cytosine ==> 3-methylcytosine; N-methyl-N-nitrosourea) [c]: CSN + MNU ⇒ m3CSN + NU DNA base ethylation (cytosine ==> 3-ethylcytosine; ethyl nitrosourea) [c]: CSN + ENU ⇒ e3CSN + NU DNA base ethylation (thymine ==> 4'-O-ethylthymine; ethyl nitrosourea) [c]: ENU + THY ⇒ NU + O4eTHY DNA base methylation (adenine ==> 1-methyladenine; N-methyl-N-nitrosourea) [c]: AD + H + MNU ⇒ m1AD + NU DNA base methylation (cytosine ==> 2'-O-methylcytosine; N-methyl-N-nitrosourea) [c]: CSN + MNU ⇒ NU + O2mCSN DNA base ethylation (cytosine ==> 2'-O-ethylcytosine; ethyl nitrosourea) [c]: CSN + ENU ⇒ NU + O2eCSN DNA base ethylation (guanine ==> 6'-O-ethylguanine; ethyl nitrosourea) [c]: ENU + GN ⇒ NU + O6eGN DNA base methylation (thymine ==> 3'-methylthymine; N-methyl-N-nitrosourea) [c]: MNU + THY ⇒ m3THY + NU DNA base ethylation (thymine ==> 2'-O-ethylthymine; ethyl nitrosourea) [c]: ENU + THY ⇒ NU + O2eTHY DNA base ethylation (guanine ==> 7-ethylguanine; ethyl nitrosourea) [c]: ENU + GN ⇒ e7GN + NU

Comments
Comments	byproduct of DNA methylation by MNU

Metadata
Created	2012-10-01 15:07:04
Last updated	2012-10-01 15:12:24