MG_278_MONOMER – GTP diphosphokinase

Name
WID MG_278_MONOMER View in model
Name GTP diphosphokinase View in model
 
Genetics
Gene MG_278 View in model
 
Structure
Sequence
1
51
101
151
201
251
301
351
401
451
501
551
601
651
701
MATIQEIECDFLAKIAQKFTNAEIELINKAFYHAKTWHENQKRLSGEPFF
IHPLRTALSLVEWNMDPITICAGLLHDIIEDTDQTEANIAMIFSKEIAEL
VTKVTKITNESKKQRHLKNKKENLNLKSFVNIAINSQQEINVMVLKLADR
LDNIASIEFLPIEKQKVIAKETLELYAKIAGRIGMYPVKTKLADLSFKVL
DLKNYDNTLSKINKQKVFYDNEWDNFKQQLKKILAQNQIEYQLESRIKGI
YSTYKKLTVHEQNISKIHDLFAIRLITKSELDCYHILGLIHLNFLIDSKY
FKDYIASPKQNLYQSIHTTVRLKGLNVEIQIRTQQMDNVSKFGLASHWIY
KEQKEGLLAPALQLNYLVTKQKHSHDFLKRIFGTDIIKINVSASHEPNVI
KQINVDSNNKLLDIAFENYPKQFAKLTKIEIDGVEINSFDTSVENEMLIE
FYFGKNNNLKSKWIRYMNNPIYREKVKKSLAKLAKSGRYSELAFYEKELG
EKQLKLASETEIQKRLNTLRIKKMSDYLALIECTNFTNDEHLLFLAKNND
KWNKLTKPLKFAFSKVVFHNSYFEQIEGIFITKIVIEPCCSKIPDMPEQV
TGILTKNILSVHRYGCKNLQNKKQLKIIPLYWNIQQLKLKPRKFRSYINI
NGVWSEKTINKICQTIINGDGYIEKIIPKINKQKDEFDLNITLFVNNYQQ
LLTLMDQITTKNISFSWKYL*
50
100
150
200
250
300
350
400
450
500
550
600
650
700
721
 View in model
Is N‑terminal methionine cleaved
No
 View in model
Prosthetic groups View in model
Empirical formula (pH 7.5) H6131C3837N1001O1080S19
Molecular weight (pH 7.5; Da) 84173.78 View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)		 92220
Instability index 42.38
Is stable False
Aliphatic index 100.90
GRAVY (25C, pH 7.0) -0.365
Half life (OD (600 nm) = 0.3, 
M9 media, 36C; min)		 1200 View in model
 
Synthesis
Localization c View in model
 
Function
Complex subunit GTP pyrophosphokinase
[c]: (2) MG_278_MONOMER ⇒ MG_278_DIMER		 View in model
 
Comments
Comments Functional Macromolecule Functional as homodimer [PUB_0338]. Dimerization regulates activity [PUB_0338]. Coenzymes Monomer interacts with MN with unknown stoichiometry as prosthetic group [96].
References

  1. Yang X, Ishiguro EE. Dimerization of the RelA protein of Escherichia coli. Biochem Cell Biol 79, 729-36 (2001). WholeCell: PUB_0338, PubMed: 11800013
 
Metadata
Created 2012-10-01 15:07:56
Last updated 2012-10-01 15:14:39