MG_270 – lipoyltransferase/lipoate-protein ligase, putative

Name
WID MG_270 View in model
Name lipoyltransferase/lipoate-protein ligase, putative View in model
Symbol lplA
Protein product MG_270_MONOMER
Cross references GenBank: AAC71492.1, CMR: MG_270, BioCyc: MG_270, SwissProt: P47512
Homologs
 
Classification
Type mRNA View in model
 
Structure
Structure 324933330944 MG_268 MG_269 MG_270 MG_271 MG_272 View in model
Sequence Chromosome: Mgenitalium_Chr_1, Coordinate: 327433 (nt), Length: 1011 (nt), Direction: Reverse, G/C content: 32.9%, Sequence:
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ATGCAAACTTTCATTATTACTTCCCCTGTTTTCAATCCGTATTTTAATGC
AGCTTTAGAGGAGTGATTGCTAACTGAATTTAGAAAAAATGAGTTAGTTA
AGGTCATCTACTTTTGGCAGAACGCTAACACTATTGTGGTGGGAAGAAAC
CAAAATACTTATGCTGAGGTTAACTTAAAGGAGTTGGAAAGTGATAAGGT
TAACTTGTTTAGACGTTTTTCAGGCGGGGGAGCGGTGTTTCATGACCTTG
GTAACATCTGTTTTTCTATTATTTTGCCAAGAACAGGTAAAGTGATGGAA
AATGCTTATGAACAAACTACAAGAAATGTGGTGAAGTTCTTAAATAGCTT
AAATGTACCTGCTGTATTTCATGGTCGTAATGACCTTGAGATTAATAACA
AGAAGTTTTCTGGGTTAGCTGAATATATCGCTAAAGACAGGTTATTAGTC
CATGGAACATTATTGTTTGACACTGACTTTTCTAAGTTAGCAAAGTATTT
AAATGTTGATAAGACCAAGATAGCAAGTAAGGGTGTTGACAGTGTTGCTA
AGCGCGTTGTTAATGTAAAGGAGTATTTACCAAATTGAACAACAGCAAAA
TTTTTAGAAGAGATGATTAATTTTTTCACTGTTACTGAAAAAGCAGAAAC
AATTGTTTTAACTAAAGATGCACTAGCAAAGGTTGAAAAAAGAGCAAAAG
AACACTTTCAATCATGGGAGTGAAACTTTGGTAAAACTTATGAATACAAC
TTTAAAAACAAGCGTTATTTTAATAATGCTGGTTTATTTGAGTGCAATGT
TCAAGTAGAGAAAGGAACAGTTGTTGATATTAAGTTTTATGGGGACTTTT
TAAGTGTTGTTGATATCACCCCAGTAACAAAAAAACTAATTGGTCAGAAG
TACGATTATAAAACCTTTGAAAAACTCTTCAATGAACTTGATCATTTTAG
TGATTACTTTGGCAGTTTAAAACCTGAGCAACTCTTAGGAGTAATATTTG
ATAACAAGTAA
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1011
 View in model
Transcription unit TU_180 View in model
Empirical formula (pH 7.5) H10794C9782N4071O7056P1011
Molecular weight (pH 7.5; Da) 329595.49 View in model
 
Functional genomics
Is essential
Yes (Show evidence)
 View in model
Relative expression
0.851454 (dimensionless) (Show evidence)
 View in model
Half life
5.7 (min) (Show evidence)
 View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)		 10499700
pI 4.06
 
Comments
Comments Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [PUB_0110];
References

  1. Bernstein JA, Khodursky AB, Lin PH, Lin-Chao S, Cohen SN. Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A 99, 9697-702 (2002). WholeCell: PUB_0602, PubMed: 12119387

  2. Chen J, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler-Bauer A, Marchler GH, Mazumder R, Nikolskaya AN, Rao BS, Panchenko AR, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH. MMDB: Entrez's 3D-structure database. Nucleic Acids Res 31, 474-7 (2003). WholeCell: PUB_0110, PubMed: 12520055, URL: http://www.ncbi.nlm.nih.gov/Structure/

  3. Glass JI, Assad-Garcia N, Alperovich N, Yooseph S, Lewis MR, Maruf M, Hutchison CA 3rd, Smith HO, Venter JC. Essential genes of a minimal bacterium. Proc Natl Acad Sci U S A 103, 425-30 (2006). WholeCell: PUB_0193, PubMed: 16407165

  4. Weiner J 3rd, Zimmerman CU, Göhlmann HW, Herrmann R. Transcription profiles of the bacterium Mycoplasma pneumoniae grown at different temperatures. Nucleic Acids Res 31, 6306-20 (2003). WholeCell: PUB_0569, PubMed: 14576319
 
Metadata
Created 2012-10-01 15:07:22
Last updated 2012-10-01 15:13:18