MG_171_MONOMER – adenylate kinase

Name
WID	MG_171_MONOMER
Name	adenylate kinase
Cross references	PDB: 1AKE, PDB: 4AKE

Genetics
Gene	MG_171

Structure
Sequence	1 51 101 151 201 MVAQFNKFIILGPPGAGKGTVCKLLSKTTKLVHIASGDLFREAIKNQSVI GRKIAAIISQGGYVDDATTNQLVYEYITTNPLPNGFILDGYPRTENQLDF LNIKLTIDMVFELVVSDLNKLITRIDNRVICNNCNSVYNLLFQKPLVENS CDQCSAKLVKRSDDNKAVVKARMELYQQTIQPIHTYFFNKQLLVQIDCFL PLEEQLKTIKQFIR* 50 100 150 200 215
Is N‑terminal methionine cleaved	No
Prosthetic groups	(None) MG [c]
Empirical formula (pH 7.5)	H₁₇₆₂C₁₀₉₃N₂₈₉O₃₁₄S₉
Molecular weight (pH 7.5; Da)	24263.95
Extinction coefficient (260 nm, 25C, pH 7.0)	11180
Instability index	26.61
Is stable	True
Aliphatic index	106.05
GRAVY (25C, pH 7.0)	-0.0372
Half life (OD (600 nm) = 0.3, M9 media, 36C; min)	1200

Synthesis
Localization	c

Function
Enzyme	adenylate kinase (ATP) [c]: AMP + ATP ⇔ (2) ADP adentylate kinase (GTP) [c]: AMP + GTP ⇔ ADP + GDP adentylate kinase (ITP) [c]: AMP + ITP ⇔ ADP + IDP deoxyadenylate kinase (dADP) [c]: ATP + DAMP ⇔ ADP + DADP deoxyadenylate kinase (dA:ATP) [c]: ATP + DA ⇒ ADP + DAMP + H

Comments
Comments	Functional Macromolecule Functional as monomer [PUB_0351]. Coenzymes Monomer interacts with MG with unknown stoichiometry as prosthetic group.
References	Goelz SE, Cronan JE Jr. Adenylate kinase of Escherichia coli: evidence for a functional interaction in phospholipid synthesis. Biochemistry 21, 189-95 (1982). WholeCell: PUB_0351, PubMed: 6277367

Metadata
Created	2012-10-01 15:07:51
Last updated	2012-10-01 15:14:31