Gmk4 – deoxyguanylate kinase (dGMP:dATP)

Name
WID Gmk4 View in model
Name deoxyguanylate kinase (dGMP:dATP) View in model
Cross references EC: 2.7.4.8, KEGG: R00332
 
Classification
Type chemical View in model
 
Reaction
Stoichiometry [c]: DATP + DGMP ⇔ DADP + DGDP View in model
 
Catalysis
Enzyme MG_107_DIMER [c] View in model
Optimal pH
7.6 (dimensionless)
Optimal temperature
31.0 (C)
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) 0.0
Keq
1.0 ()
 
Kinetics
Forward kinetics v = Vmax * [DGMP] / (Km + [DGMP]); Km = 300 (nM), Vmax = 11.0 U/mg View in model
 
Associations
Pathways NUCLEOTIDE_SALVAGE_PWY
Process Process_Metabolism View in model
 
Comments
Comments dGMP can also act as acceptor [PUB_0413]; dATP can also act as donor [PUB_0413];
References

  1. Bao J, Ryu DD. Total biosynthesis of deoxynucleoside triphosphates using deoxynucleoside monophosphate kinases for PCR application. Biotechnol Bioeng 98, 1-11 (2007). WholeCell: PUB_0413, PubMed: 17514761
 
Metadata
Created 2012-10-01 15:08:37
Last updated 2012-10-01 15:16:41