GlyA3 – glycine hydroxymethyltransferase, reversible

WID GlyA3 View in model
Name glycine hydroxymethyltransferase, reversible View in model
Cross references EC:, BiGG: GHMT2r, BioCyc: GLYOHMETRANS-RXN, KEGG: R00945
Type chemical View in model
Stoichiometry [c]: (2) H + SER + THFGLY + H2O + METTHF View in model
Enzyme MG_394_TETRAMER [c] View in model
  • PL5P [c] (Show evidence)

View in model
Optimal pH
7.6 (dimensionless)
Optimal temperature
49.0 (C)
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) 0.100
0.84696481244 ()
Forward kinetics
v = Vmax * [SER] * [THF] / (Km1 * Km2 + Km1 * [SER] + Km2 * [THF]); Km1 = 80 (nM), Km2 = 150 (nM), Vmax = 13.6 U/mg (Show evidence)
View in model
Process Process_Metabolism View in model
  1. Chang A, Scheer M, Grote A, Schomburg I, Schomburg D. BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009. Nucleic Acids Res 37, D588-92 (2009). WholeCell: PUB_0570, PubMed: 18984617

  2. Keseler IM, Bonavides-Martínez C, Collado-Vides J, Gama-Castro S, Gunsalus RP, Johnson DA, Krummenacker M, Nolan LM, Paley S, Paulsen IT, Peralta-Gil M, Santos-Zavaleta A, Shearer AG, Karp PD. EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res 37, D464-70 (2009). WholeCell: PUB_0006, PubMed: 18974181

  3. UniProt Consortium. The Universal Protein Resource (UniProt) 2009. Nucleic Acids Res 37, D169-74 (2009). WholeCell: PUB_0096, PubMed: 18836194, URL:

  4. Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL:

Created 2012-10-01 15:08:35
Last updated 2012-10-01 15:16:35