FthC – methylenetetrahydrofolate cyclohydrase

Name
WID	FthC
Name	methylenetetrahydrofolate cyclohydrase
Cross references	EC: 6.3.3.2

Classification
Type	chemical

Reaction
Stoichiometry	[c]: ATP + FTHF10 + (3) H ⇔ ADP + METTHF + PI

Catalysis
Enzyme	MG_245_MONOMER [c]
Optimal pH	6.7 (dimensionless)
Optimal temperature	31.0 (C)

Energetics
Is spontaneous (pH 7.5, 25C, I = 0)	False
ΔG (pH 7.5, 25C, I = 0; kJ mol^‑1)	-4.30
K_eq	1264.122842 ()

Kinetics
Forward kinetics	v = V_max * [FTHF10] / (K_m + [FTHF10]); K_m = 2 (nM), V_max = 37.0 U/mg (Show evidence) Value: Rate law: VmaxFTHF/(Km+FTHF); Km = 0.002 mM, Vmax = 37 umol/(minmg) (None) Measured: Yes Species: Homo sapiens References Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/

Associations
Pathways	FOLATE_METABOLISM
Process	Process_Metabolism

Comments
References	Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/

Metadata
Created	2012-10-01 15:08:34
Last updated	2012-10-01 15:16:32