FTHF5 – 5-formyltetrahydrofolate

Name
WID	FTHF5
Name	5-formyltetrahydrofolate
Traditional name	foliinic acid
IUPAC name	2-[(4-{[(2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
Cross references	ChEBI: 15640, BioCyc: 5-FORMYL-THF, CAS: 58-05-9, PubChem: 6294, ThreeDMET: B04899, KEGG: C03479

Classification
Type	vitamin_folate

Structure
Empirical formula (pH 7.5)	H₂₃C₂₀N₇O₇
SMILES (pH 7.5)	NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2C=O)N1
Charge (pH 7.5)	-2
Is hydrophobic	False
Molecular weight (Da)	473.44
van der Waals volume (pH 7.5; Å³ molecule^‑1)	394.80
Δ_fG^'o (pH 7.5, 25C, I = 0; kJ mol^‑1)	392.20
pI	4.39
logP	-3.96
logD (pH 7.5)	-8.77

Function
Reaction participant	tRNA uridine 5-carboxymethylaminomethyl modification enzyme [c]: FTHF5 + GLY + s2UMP ⇒ cmnm5s2UMP + H2O + THF 5,10-methenyltetrahydrofolate hydrolysis [c]: H + H2O + METHF ⇒ FTHF5 tRNA uridine 5-carboxymethylaminomethyl modification enzyme [c]: FTHF5 + GLY + s2UMP ⇒ cmnm5s2UMP + H2O + THF tRNA uridine 5-carboxymethylaminomethyl modification enzyme [c]: FTHF5 + GLY + s2UMP ⇒ cmnm5s2UMP + H2O + THF

Metadata
Created	2012-10-01 15:06:57
Last updated	2012-10-01 15:12:09