FAPydA – N4-(2-Deoxy-alpha,beta-D-erythro-pentofuranosyl)-4,6-diamino-5-formamidopyrimidine

Name
WID	FAPydA
Name	N4-(2-Deoxy-alpha,beta-D-erythro-pentofuranosyl)-4,6-diamino-5-formamidopyrimidine
Traditional name	N-(4-amino-6-{[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]amino}pyrimidin-5-yl)formamide
IUPAC name	N-(4-amino-6-{[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]amino}pyrimidin-5-yl)formamide

Classification
Type	modified_deoxyribonucleoside

Structure
Empirical formula (pH 7.5)	H₁₅C₁₀N₅O₄
SMILES (pH 7.5)	C1C(C(OC1NC2=C(NC=O)C(=NC=N2)N)CO)O
Charge (pH 7.5)	0
Is hydrophobic	False
Molecular weight (Da)	269.26
van der Waals volume (pH 7.5; Å³ molecule^‑1)	226.73
pI	9.15
logP	-1.81
logD (pH 7.5)	-1.89

Function
Reaction participant	N4-(2-Deoxy-alpha,beta-D-erythro-pentofuranosyl)-4,6-diamino-5-formamidopyrimidine transport FAPydA[e] ⇔ FAPydA[c] 5'-nucleotidase (N4-(2-Deoxy-alpha,beta-D-erythro-pentofuranosyl)-4,6-diamino-5-formamidopyrimidine monophosphate) [c]: FAPydAMP + H2O ⇒ FAPydA + PI

Comments
Comments	28.5 lesions per 10^6 bases [PUB_0479];
References	Guetens G, De Boeck G, Highley M, van Oosterom AT, de Bruijn EA. Oxidative DNA damage: biological significance and methods of analysis. Crit Rev Clin Lab Sci 39, 331-457 (2002). WholeCell: PUB_0479, PubMed: 12385502

Metadata
Created	2012-10-01 15:06:57
Last updated	2012-10-01 15:12:09