DhfR1 – dihydrofolate reductase
Name | ||
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WID | DhfR1 |
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Name | dihydrofolate reductase |
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Cross references | EC: 1.5.1.3, SABIO-RK: 100, BiGG: DHFR, BioCyc: DIHYDROFOLATEREDUCT-RXN, KEGG: R00939 | |
Classification | ||
Type | chemical |
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Reaction | ||
Stoichiometry | [c]: DHF + H + NADPH ⇔ NADP + THF |
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Catalysis | ||
Enzyme | MG_228_TETRAMER [c] |
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Optimal pH | 4.7 (dimensionless) |
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Optimal temperature | 33.0 (C) |
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Energetics | ||
Is spontaneous (pH 7.5, 25C, I = 0) | False |
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ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) | -0.200 | |
Keq | 1.39402083426 () |
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Kinetics | ||
Forward kinetics | v = Vmax * [DHF] / (Km + [DHF]); Km = 0.89 (nM), Vmax = 370.8 1/min |
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Backward kinetics |
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Associations | ||
Pathways | COFACTOR_PROSTHETIC_BIOSYNTHESIS | |
Process | Process_Metabolism |
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Comments | ||
References |
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Metadata | ||
Created | 2012-10-01 15:08:09 | |
Last updated | 2012-10-01 15:15:06 |