DhfR1 – dihydrofolate reductase

Name
WID DhfR1 View in model
Name dihydrofolate reductase View in model
Cross references EC: 1.5.1.3, SABIO-RK: 100, BiGG: DHFR, BioCyc: DIHYDROFOLATEREDUCT-RXN, KEGG: R00939
 
Classification
Type chemical View in model
 
Reaction
Stoichiometry [c]: DHF + H + NADPH ⇔ NADP + THF View in model
 
Catalysis
Enzyme MG_228_TETRAMER [c] View in model
Optimal pH
4.7 (dimensionless)
Optimal temperature
33.0 (C)
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) -0.200
Keq
1.39402083426 ()
 
Kinetics
Forward kinetics v = Vmax * [DHF] / (Km + [DHF]); Km = 0.89 (nM), Vmax = 370.8 1/min View in model
Backward kinetics
(Show evidence)
 View in model
 
Associations
Pathways COFACTOR_PROSTHETIC_BIOSYNTHESIS
Process Process_Metabolism View in model
 
Comments
References

  1. Keseler IM, Bonavides-Martínez C, Collado-Vides J, Gama-Castro S, Gunsalus RP, Johnson DA, Krummenacker M, Nolan LM, Paley S, Paulsen IT, Peralta-Gil M, Santos-Zavaleta A, Shearer AG, Karp PD. EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res 37, D464-70 (2009). WholeCell: PUB_0006, PubMed: 18974181

  2. Wittig U, Golebiewski M, Kania R, Krebs O, Mir S, Weidemann A, Anstein S, Saric J, Rojas I. In proceedings of the 3rd International workshop on Data Integration in the Life Sciences 2006. Lecture Notes in Bioinformatics 4075, 94-103 (2006). WholeCell: PUB_0100, URL: http://sabio.villa-bosch.de/
 
Metadata
Created 2012-10-01 15:08:09
Last updated 2012-10-01 15:15:06