DNA_RM_EcoD_Methylation – EcoD DNA restriction/modification, DNA base methylation (adenine ==> 6-methyladenine; S-Adenosyl-L-methionine)

Name
WID DNA_RM_EcoD_Methylation View in model
Name EcoD DNA restriction/modification, DNA base methylation (adenine ==> 6-methyladenine; S-Adenosyl-L-methionine) View in model
 
Classification
Type DNA_restriction_modification View in model
 
Reaction
Stoichiometry [c]: AD + AMET ⇒ AHCYS + H + m6AD View in model
 
Catalysis
Enzyme MG_438_MONOMER [c] View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
 
Kinetics
Forward kinetics View in model
 
Associations
Process Process_DNARepair View in model
 
Comments
Comments EcoD type I restriction/modification methylation reaction. EcoD recognizes the sequence 5'-TCARTTC-3' [PUB_0006]. The other subunits of the EcoD restriction/modification system methylate the N6 position of A-3 of hemimethylated DNA producing N6-methyladenine, and cleave unmethylated DNA [PUB_0006]. M. genitalium only contains the DNA recognition subunit of the EcoD restriction/modification system.
References

  1. Keseler IM, Bonavides-Martínez C, Collado-Vides J, Gama-Castro S, Gunsalus RP, Johnson DA, Krummenacker M, Nolan LM, Paley S, Paulsen IT, Peralta-Gil M, Santos-Zavaleta A, Shearer AG, Karp PD. EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res 37, D464-70 (2009). WholeCell: PUB_0006, PubMed: 18974181
 
Metadata
Created 2012-10-01 15:08:09
Last updated 2012-10-01 15:15:07