DNA_POLYMERASE_HOLOENZYME – DNA-directed DNA polymerase holoenzyme

Name
WID DNA_POLYMERASE_HOLOENZYME View in model
Name DNA-directed DNA polymerase holoenzyme View in model
 
Structure
Biosynthesis [c]: (2) DNA_POLYMERASE_CORE + DNA_POLYMERASE_GAMMA_COMPLEX + (2) MG_001_MONOMER ⇒ DNA_POLYMERASE_HOLOENZYME View in model
No. subunits 2
Empirical formula (pH 7.5) H69016C43891N11282O12706S195
Molecular weight (pH 7.5; Da) 964287.50 View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)		 744050.00
Half life (OD (600 nm) = 0.3, 
M9 media, 36C; min)		 1200.00 View in model
 
Synthesis
Formation process Process_Replication View in model
Localization c
 
Function
Complex subunit DNA-directed DNA polymerase holoenzyme
[c]: (2) DNA_POLYMERASE_CORE + DNA_POLYMERASE_GAMMA_COMPLEX + (2) MG_001_MONOMER ⇒ DNA_POLYMERASE_HOLOENZYME		 View in model
 
Parameters
Parameters Parameter_0109: dnaPolymeraseElongationRate = 100 nt/s View in model
 
Comments
Comments Composition [PUB_0312, PUB_0313, PUB_0314].
References

  1. Bruck I, O'Donnell M. The DNA replication machine of a gram-positive organism. J Biol Chem 275, 28971-83 (2000). WholeCell: PUB_0314, PubMed: 10878011

  2. Kelman Z, O'Donnell M. DNA polymerase III holoenzyme: structure and function of a chromosomal replicating machine. Annu Rev Biochem 64, 171-200 (1995). WholeCell: PUB_0312, PubMed: 7574479

  3. Razin S, Yogev D, Naot Y. Molecular biology and pathogenicity of mycoplasmas. Microbiol Mol Biol Rev 62, 1094-156 (1998). WholeCell: PUB_0313, PubMed: 9841667
 
Metadata
Created 2012-10-01 15:07:36
Last updated 2012-10-01 15:14:01