DNADamage_m5CSN_hm5CSN_hydroxyl_radical – DNA radiation (gamma-ray) induced base oxidation (5-methylcytosine ==> 5'-hydroxymethylcytosine; hydroxyl radical)

Name
WID DNADamage_m5CSN_hm5CSN_hydroxyl_radical View in model
Name DNA radiation (gamma-ray) induced base oxidation (5-methylcytosine ==> 5'-hydroxymethylcytosine; hydroxyl radical) View in model
 
Classification
Type radiation_induced_base_oxidation View in model
 
Reaction
Stoichiometry gamma_radiation[e] + hydroxyl_radical[c] + m5CSN[c] ⇒ H[c] + hm5CSN[c] View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) True View in model
 
Associations
Process Process_DNADamage View in model
 
Comments
Comments [PUB_0507]. Reaction rate computed from 1) total gamma ray base damage yield 1.7e-9 1/Gy/DA [PUB_0497], 2) 305 nt/DA, and 3) relative yields of various damaged bases [PUB_0461, PUB_0501].
References

  1. Cannon SV, Cummings A, Teebor GW. 5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue. Biochem Biophys Res Commun 151, 1173-9 (1988). WholeCell: PUB_0507, PubMed: 3355548

  2. Dizdaroglu M. Measurement of radiation-induced damage to DNA at the molecular level. Int J Radiat Biol 61, 175-83 (1992). WholeCell: PUB_0501, PubMed: 1351904

  3. Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. DNA repair and mutagenesis. ASM Press (2006). WholeCell: PUB_0461, ISBN: 9781555813192

  4. Gulston M, Fulford J, Jenner T, de Lara C, O'Neill P. Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res 30, 3464-72 (2002). WholeCell: PUB_0497, PubMed: 12140332
 
Metadata
Created 2012-10-01 15:08:31
Last updated 2012-10-01 15:16:23