DNADamage_AD_FAPyAD_hydroxyl_radical – DNA radiation (gamma-ray) induced base oxidation (adenine ==> 4,6-diamino-5-N-formamidopyrimidine; hydroxyl radical)

WID DNADamage_AD_FAPyAD_hydroxyl_radical View in model
Name DNA radiation (gamma-ray) induced base oxidation (adenine ==> 4,6-diamino-5-N-formamidopyrimidine; hydroxyl radical) View in model
Type radiation_induced_base_oxidation View in model
Stoichiometry AD[c] + gamma_radiation[e] + H[c] + hydroxyl_radical[c] ⇒ FAPyAD[c] View in model
Is spontaneous (pH 7.5, 25C, I = 0) True View in model
Process Process_DNADamage View in model
Comments Lesion caused by ROS [PUB_0472]. Reaction rate computed from 1) total gamma ray base damage yield 1.7e-9 1/Gy/DA [PUB_0497], 2) 305 nt/DA, and 3) relative yields of various damaged bases [PUB_0461, PUB_0501].
  1. Dizdaroglu M. Measurement of radiation-induced damage to DNA at the molecular level. Int J Radiat Biol 61, 175-83 (1992). WholeCell: PUB_0501, PubMed: 1351904

  2. Friedberg EC, Walker GC, Siede W, Wood RD, Schultz RA, Ellenberger T. DNA repair and mutagenesis. ASM Press (2006). WholeCell: PUB_0461, ISBN: 9781555813192

  3. Gulston M, Fulford J, Jenner T, de Lara C, O'Neill P. Clustered DNA damage induced by gamma radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Res 30, 3464-72 (2002). WholeCell: PUB_0497, PubMed: 12140332

  4. Haraguchi K, Delaney MO, Wiederholt CJ, Sambandam A, Hantosi Z, Greenberg MM. Synthesis and characterization of oligonucleotides containing formamidopyrimidine lesions (Fapy.dA, Fapy.dG) at defined sites. Nucleic Acids Res Suppl 269, 129-30 (2001). WholeCell: PUB_0472, PubMed: 12836298

Created 2012-10-01 15:08:29
Last updated 2012-10-01 15:16:14