DHURA – 5,6-dihydroxyuracil; dialuric acid

Name
WID	DHURA
Name	5,6-dihydroxyuracil; dialuric acid
Traditional name	5,6-dihydroxy-1,3-dihydropyrimidine-2,4-dione
IUPAC name	5,6-dihydroxy-1,2,3,4-tetrahydropyrimidine-2,4-dione
Cross references	CAS: 42608-53-7, PubChem: 8191706

Classification
Type	modified_nucleobase

Structure
Empirical formula (pH 7.5)	H₄C₄N₂O₄
SMILES (pH 7.5)	N1C(=C(C(=O)NC1=O)O)O
Charge (pH 7.5)	0
Is hydrophobic	False
Molecular weight (Da)	144.09
van der Waals volume (pH 7.5; Å³ molecule^‑1)	105.68
logP	-0.970
logD (pH 7.5)	-1.02

Function
Reaction participant	DNA radiation (gamma-ray) induced base oxidation (uracil ==> 5,6-dihydroxyuracil; dialuric acid; hydroxyl radical) gamma_radiation[e] + (2) hydroxyl_radical[c] + URA[c] ⇒ DHURA[c] + (2) H[c] DNA radiation (gamma-ray) induced base oxidation (5,6-dihydroxyuracil; dialuric acid ==> 5-hydroxyhydantoin; hydroxyl radical) DHURA[c] + gamma_radiation[e] + H2O[c] ⇒ CO2[c] + (2) H[c] + ho5hydantoin[c]

Metadata
Created	2012-10-01 15:06:54
Last updated	2012-10-01 15:12:03