ADP – ADP

Name
WID	ADP
Name	ADP
Traditional name	[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (phosphonatooxy)phosphonate
IUPAC name	[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl (phosphonatooxy)phosphonate
Cross references	ChEBI: 16761, CAS: 20398-34-9, PubChem: 3310, BioCyc: ADP, BiGG: adp, ... 4 more

Classification
Type	ribonucleotide_diphosphate

Structure
Empirical formula (pH 7.5)	H₁₂C₁₀N₅O₁₀P₂
SMILES (pH 7.5)	NC1=NC=NC2=C1N=CN2C1OC(COP([O-])(=O)OP([O-])([O-])=O)C(O)C1O
Charge (pH 7.5)	-3
Is hydrophobic	False
Molecular weight (Da)	424.18
van der Waals volume (pH 7.5; Å³ molecule^‑1)	298.70
Δ_fG^'o (pH 7.5, 25C, I = 0; kJ mol^‑1)	-1392.20
pI	2.70
logP	-5.57
logD (pH 7.5)	-7.59

Function
Complex subunit	Chromosome Segregation Protein SMC with SCP Proteins-ADP [c]: ADP + MG_213_214_298_6MER ⇒ MG_213_214_298_6MER_ADP DnaA-ADP [c]: ADP + MG_469_MONOMER ⇒ MG_469_1MER_ADP
Reaction participant	Protein degradation (ALA) [c]: AlaAla + ATP + (2) H2O ⇒ ADP + (2) ALA + H + PI Protein degradation (PHE) [c]: ATP + (2) H2O + PhePhe ⇒ ADP + H + (2) PHE + PI protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER ... 190 more protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR Protein degradation (SER) [c]: ATP + (2) H2O + SerSer ⇒ ADP + H + PI + (2) SER protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR RNA cleavage (AMP) [c]: ApAp + ATP + (2) H2O ⇒ ADP + (2) AMP + (2) H + PI protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER glycerol transport via ABC system ATP[c] + GL[e] + H2O[c] ⇒ ADP[c] + GL[c] + H[c] + PI[c] thiamine-phosphate kinase [c]: ATP + THMP ⇔ ADP + TPP protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER oligopeptide (Gln) transport via ABC system ATP[c] + GlnGln[e] + H2O[c] ⇒ ADP[c] + GlnGln[c] + H[c] + PI[c] protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER deoxyadenylate kinase (dA:ATP) [c]: ATP + DA ⇒ ADP + DAMP + H protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR phosphoglycerate kinase [c]: ADP + DPG ⇔ ATP + G3P Protein degradation (LYS) [c]: ATP + (2) H2O + LysLys ⇒ ADP + H + (2) LYS + PI thiamine kinase [c]: ATP + DTMP ⇔ ADP + DTDP Protein degradation (THR) [c]: ATP + (2) H2O + ThrThr ⇒ ADP + H + PI + (2) THR fructose-1-phosphate kinase [c]: ATP + F1P ⇒ ADP + FDP + H protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER adentylate kinase (GTP) [c]: AMP + GTP ⇔ ADP + GDP oligopeptide (Tyr) transport via ABC system ATP[c] + H2O[c] + TyrTyr[e] ⇒ ADP[c] + H[c] + PI[c] + TyrTyr[c] glutamyl-tRNA (MG502) amidotransferase [c]: ATP + GLN + GLU + H2O ⇒ ADP + GLN + GLU + H + PI oligopeptide (Arg) transport via ABC system ArgArg[e] + ATP[c] + H2O[c] ⇒ ADP[c] + ArgArg[c] + H[c] + PI[c] phosphate transport via ABC system ATP[c] + H2O[c] + PI[e] ⇒ ADP[c] + H[c] + (2) PI[c] Protein degradation (GLY) [c]: ATP + GlyGly + (2) H2O ⇒ ADP + (2) GLY + H + PI alpha-L-glutamate ligase [c]: (4) ATP + (4) GLU + (4) H2O ⇒ (4) ADP + (4) H + (4) H2O + (4) PI pyruvate kinase [c]: ADP + H + PEP ⇔ ATP + PYR iron (II) transporting ATPase ATP[c] + FE2[e] + H2O[c] ⇒ ADP[c] + FE2[c] + H[c] + PI[c] protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER Protein degradation (ALA) [c]: AlaAla + ATP + (2) H2O ⇒ ADP + (2) ALA + H + PI protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR oligopeptide (Trp) transport via ABC system ATP[c] + H2O[c] + TrpTrp[e] ⇒ ADP[c] + H[c] + PI[c] + TrpTrp[c] deoxyadenylate kinase (dADP) [c]: ATP + DAMP ⇔ ADP + DADP protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR cytidylate kinase (CMP) [c]: ATP + CMP ⇔ ADP + CDP protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR drug efflux (doxorubicin) via ABC system ATP[c] + doxorubicin[c] + H2O[c] ⇒ ADP[c] + doxorubicin[e] + H[c] + PI[c] dephospho-CoA kinase [c]: ATP + DPCOA ⇒ ADP + COA + H Protein degradation (ASN) [c]: AsnAsn + ATP + (2) H2O ⇒ ADP + (2) ASN + H + PI protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR UMP kinase [c]: ATP + UMP ⇔ ADP + UDP protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR sulfate transporting ATPase ATP[c] + H2O[c] + SO4[e] ⇒ ADP[c] + H[c] + PI[c] + SO4[c] Protein degradation (THR) [c]: ATP + (2) H2O + ThrThr ⇒ ADP + H + PI + (2) THR protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR ribonucleoside-diphosphate reductase (ADP) [c]: (2) ADP + MG_229_231_TETRAMER + O2 ⇒ (2) DADP + (2) H2O + MG_229_231_TETRAMER_ox oligopeptide (His) transport via ABC system ATP[c] + H2O[c] + HisHis[e] ⇒ ADP[c] + H[c] + HisHis[c] + PI[c] Protein degradation (CYS) [c]: ATP + CysCys + (2) H2O ⇒ ADP + (2) CYS + H + PI adentylate kinase (ITP) [c]: AMP + ITP ⇔ ADP + IDP protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR RNA cleavage (GMP) [c]: ATP + GpGp + (2) H2O ⇒ ADP + (2) GMP + (2) H + PI Protein degradation (MET) [c]: ATP + (2) H2O + MetMet ⇒ ADP + H + (2) MET + PI protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR DNA unwinding [c]: ATP + H2O ⇒ ADP + H + PI toxin secretion (nisin) via ABC system ATP[c] + H2O[c] + nisin[c] ⇒ ADP[c] + H[c] + nisin[e] + PI[c] formate-tetrahydrofolate ligase [c]: ATP + FOR + THF ⇒ ADP + FTHF10 + PI protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER deoxyguanylate kinase (dG:ATP) [c]: ATP + DG ⇒ ADP + DGMP + H thymidine kinase (ATP:thymidine) [c]: ATP + DT ⇒ ADP + DTMP + H protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR Protein degradation (PHE) [c]: ATP + (2) H2O + PhePhe ⇒ ADP + H + (2) PHE + PI protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER oligopeptide (Ala) transport via ABC system AlaAla[e] + ATP[c] + H2O[c] ⇒ ADP[c] + AlaAla[c] + H[c] + PI[c] protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER Protein degradation (ARG) [c]: ArgArg + ATP + (2) H2O ⇒ ADP + (2) ARG + H + PI protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR Protein degradation (VAL) [c]: ATP + (2) H2O + ValVal ⇒ ADP + H + PI + (2) VAL protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR oligopeptide (Ser) transport via ABC system ATP[c] + H2O[c] + SerSer[e] ⇒ ADP[c] + H[c] + PI[c] + SerSer[c] Protein degradation (LYS) [c]: ATP + (2) H2O + LysLys ⇒ ADP + H + (2) LYS + PI Protein degradation (GLN) [c]: ATP + GlnGln + (2) H2O ⇒ ADP + (2) GLN + H + PI Protein degradation (TRP) [c]: ATP + (2) H2O + TrpTrp ⇒ ADP + H + PI + (2) TRP zinc-transporting ATPase ATP[c] + H2O[c] + ZN[e] ⇒ ADP[c] + H[c] + PI[c] + ZN[c] protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR Protein degradation (LEU) [c]: ATP + (2) H2O + LeuLeu ⇒ ADP + H + (2) LEU + PI oligopeptide (Met) transport via ABC system ATP[c] + H2O[c] + MetMet[e] ⇒ ADP[c] + H[c] + MetMet[c] + PI[c] DNA incision [c]: ATP + (2) dRibose5P_dRibose5P + (3) H2O ⇒ ADP + (4) DR5P + (3) H + PI DNA recombination Holliday junction migration [c]: ATP + H2O ⇒ ADP + H + PI drug efflux (nisin) via ABC system ATP[c] + H2O[c] + nisin[c] ⇒ ADP[c] + H[c] + nisin[e] + PI[c] Negative supercoiling (gyrase) [c]: (2) ATP + (2) H2O ⇒ (2) ADP + (2) H + (2) PI protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER oligopeptide (Cys) transport via ABC system ATP[c] + CysCys[e] + H2O[c] ⇒ ADP[c] + CysCys[c] + H[c] + PI[c] protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR Protein degradation (TYR) [c]: ATP + (2) H2O + TyrTyr ⇒ ADP + H + PI + (2) TYR protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER Protein degradation (LEU) [c]: ATP + (2) H2O + LeuLeu ⇒ ADP + H + (2) LEU + PI Protein degradation (ASN) [c]: AsnAsn + ATP + (2) H2O ⇒ ADP + (2) ASN + H + PI Protein degradation (ILE) [c]: ATP + (2) H2O + IleIle ⇒ ADP + H + (2) ILE + PI RNA cleavage (UMP) [c]: ATP + (2) H2O + UpUp ⇒ ADP + (2) H + PI + (2) UMP Protein degradation (SER) [c]: ATP + (2) H2O + SerSer ⇒ ADP + H + PI + (2) SER Protein degradation (GLN) [c]: ATP + GlnGln + (2) H2O ⇒ ADP + (2) GLN + H + PI protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR Protein degradation (PRO) [c]: ATP + (2) H2O + ProPro ⇒ ADP + H + PI + (2) PRO cobalt transport via ABC system ATP[c] + CO[e] + H2O[c] ⇒ ADP[c] + CO[c] + H[c] + PI[c] protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR Protein degradation (GLU) [c]: ATP + GluGlu + (2) H2O ⇒ ADP + (2) GLU + H + PI deoxyguanylate kinase (dGMP:ATP) [c]: ATP + DGMP ⇔ ADP + DGDP protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR deoxyuridine kinase (ATP:Deoxyuridine) [c]: ATP + DU ⇒ ADP + DUMP + H protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR Protein degradation (ILE) [c]: ATP + (2) H2O + IleIle ⇒ ADP + H + (2) ILE + PI oligopeptide (Phe) transport via ABC system ATP[c] + H2O[c] + PhePhe[e] ⇒ ADP[c] + H[c] + PhePhe[c] + PI[c] NAD kinase [c]: ATP + NAD ⇔ ADP + NADP riboflavin kinase [c]: ATP + RIBFLV ⇒ ADP + FMN + H protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER spermidine transport via ABC system ATP[c] + H2O[c] + SPMD[e] ⇒ ADP[c] + H[c] + PI[c] + SPMD[c] protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER oligopeptide (Glu) transport via ABC system ATP[c] + GluGlu[e] + H2O[c] ⇒ ADP[c] + GluGlu[c] + H[c] + PI[c] Protein degradation (PRO) [c]: ATP + (2) H2O + ProPro ⇒ ADP + H + PI + (2) PRO protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR methylenetetrahydrofolate cyclohydrase [c]: ATP + FTHF10 + (3) H ⇔ ADP + METTHF + PI oligopeptide (Thr) transport via ABC system ATP[c] + H2O[c] + ThrThr[e] ⇒ ADP[c] + H[c] + PI[c] + ThrThr[c] Protein degradation (CYS) [c]: ATP + CysCys + (2) H2O ⇒ ADP + (2) CYS + H + PI cytidylate kinase (dCMP) [c]: ATP + DCMP ⇔ ADP + DCDP Protein degradation (TYR) [c]: ATP + (2) H2O + TyrTyr ⇒ ADP + H + PI + (2) TYR RNA cleavage (CMP) [c]: ATP + CpCp + (2) H2O ⇒ ADP + (2) CMP + (2) H + PI phosphofructokinase [c]: ATP + F6P ⇒ ADP + FDP + H oligopeptide (Asn) transport via ABC system AsnAsn[e] + ATP[c] + H2O[c] ⇒ ADP[c] + AsnAsn[c] + H[c] + PI[c] Protein degradation (ASP) [c]: AspAsp + ATP + (2) H2O ⇒ ADP + (2) ASP + H + PI protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER oligopeptide (Ile) transport via ABC system ATP[c] + H2O[c] + IleIle[e] ⇒ ADP[c] + H[c] + IleIle[c] + PI[c] EcoD DNA restriction/modification, DNA restriction [c]: ATP + (2) dRibose5P_dRibose5P + (3) H2O ⇒ ADP + (4) DR5P + (3) H + PI protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER DNA excision [c]: ATP + H2O ⇒ ADP + H + PI guanylate kinase (GMP:ATP) [c]: ATP + GMP ⇔ ADP + GDP acetate kinase [c]: ACTP + ADP ⇔ AC + ATP protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR glycerol kinase [c]: ATP + GL ⇒ ADP + GL3P Protein degradation (HIS) [c]: ATP + (2) H2O + HisHis ⇒ ADP + H + (2) HIS + PI D-ribose transport via ABC system ATP[c] + H2O[c] + RIB[e] ⇒ ADP[c] + H[c] + PI[c] + RIB[c] iron (III) transporting ATPase ATP[c] + FE3[e] + H2O[c] ⇒ ADP[c] + FE3[c] + H[c] + PI[c] Protein translocation (SecA) [c]: ATP + H2O ⇒ ADP + H + PI pyridoxal kinase [c]: ATP + PYDX ⇒ ADP + H + PL5P Protein degradation (GLY) [c]: ATP + GlyGly + (2) H2O ⇒ ADP + (2) GLY + H + PI adenylate kinase (ATP) [c]: AMP + ATP ⇔ (2) ADP 5'-nucleotidase (dCMP) [c]: ATP + DC ⇒ ADP + DCMP + H ATP synthase (four protons for one ATP) (periplasm) ADP[c] + (4) H[e] + H[c] + PI[c] ⇔ ATP[c] + (4) H[c] + H2O[c] Protein degradation (VAL) [c]: ATP + (2) H2O + ValVal ⇒ ADP + H + PI + (2) VAL protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR molybdate transporting ATPase ATP[c] + H2O[c] + MOBD[e] ⇒ ADP[c] + H[c] + MOBD[c] + PI[c] oligopeptide (Asp) transport via ABC system AspAsp[e] + ATP[c] + H2O[c] ⇒ ADP[c] + AspAsp[c] + H[c] + PI[c] Magnesium-transporting ATPase ATP[c] + H2O[c] + MG[e] ⇒ ADP[c] + H[c] + MG[c] + PI[c] oligopeptide (Pro) transport via ABC system ATP[c] + H2O[c] + ProPro[e] ⇒ ADP[c] + H[c] + PI[c] + ProPro[c] copper-transporting ATPase ATP[c] + CU[e] + H2O[c] ⇒ ADP[c] + CU[c] + H[c] + PI[c] Negative supercoiling (topoisomerase I) [c]: (2) ATP + (2) H2O ⇒ (2) ADP + (2) H + (2) PI nicotinic acid mononucleotide pyrophosphorylase [c]: ATP + (3) H + H2O + NAC + PRPP ⇒ ADP + NAMN + PI + PPI Protein degradation (ASP) [c]: AspAsp + ATP + (2) H2O ⇒ ADP + (2) ASP + H + PI Protein degradation (ARG) [c]: ArgArg + ATP + (2) H2O ⇒ ADP + (2) ARG + H + PI L-glutamine transport via ABC system ATP[c] + GLN[e] + H2O[c] ⇒ ADP[c] + GLN[c] + H[c] + PI[c] protein threonine phosphorylation [c]: ATP + THR ⇒ ADP + H + pTHR oxaloacetate carboxylase [c]: ATP + CO2 + H2O + PYR ⇔ ADP + (2) H + OA + PI Carbamate kinase [c]: ATP + CO2 + NH3 ⇔ ADP + CAP + H oligopeptide (Val) transport via ABC system ATP[c] + H2O[c] + ValVal[e] ⇒ ADP[c] + H[c] + PI[c] + ValVal[c] tagatose-6-phosphate kinase [c]: ATP + TAG6P ⇒ ADP + H + TAG16P DnaA reactivation [c]: ATP + MG_469_1MER_ADP ⇒ ADP + MG_469_1MER_ATP oligopeptide (Gly) transport via ABC system ATP[c] + GlyGly[e] + H2O[c] ⇒ ADP[c] + GlyGly[c] + H[c] + PI[c] putrescine transport via ABC system ATP[c] + H2O[c] + PTRC[e] ⇒ ADP[c] + H[c] + PI[c] + PTRC[c] protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER glycerol transport via ABC system ATP[c] + GL3P[e] + H2O[c] ⇒ ADP[c] + GL3P[c] + H[c] + PI[c] DNA recombination strand exchange [c]: ATP + H2O ⇒ ADP + H + PI nickel transport via ABC system ATP[c] + H2O[c] + NI[e] ⇒ ADP[c] + H[c] + NI[c] + PI[c] Protein degradation (HIS) [c]: ATP + (2) H2O + HisHis ⇒ ADP + H + (2) HIS + PI oligopeptide (Lys) transport via ABC system ATP[c] + H2O[c] + LysLys[e] ⇒ ADP[c] + H[c] + LysLys[c] + PI[c] 2-aminoethylphosphonate transport via ABC system AEPP[e] + ATP[c] + H2O[c] ⇒ ADP[c] + AEPP[c] + H[c] + PI[c] protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR Protein degradation (MET) [c]: ATP + (2) H2O + MetMet ⇒ ADP + H + (2) MET + PI oligopeptide (Leu) transport via ABC system ATP[c] + H2O[c] + LeuLeu[e] ⇒ ADP[c] + H[c] + LeuLeu[c] + PI[c] nicotinate-nucleotide adenylyltransferase [c]: ATP + NH3 + NR ⇒ ADP + NMN + PI protein serine phosphorylation [c]: ATP + SER ⇒ ADP + H + pSER Manganese-transporting ATPase ATP[c] + H2O[c] + MN[e] ⇒ ADP[c] + H[c] + MN[c] + PI[c] choline kinase [c]: ATP + CHOL ⇒ ADP + H + pCHOL protein tyrosine phosphorylation [c]: ATP + TYR ⇒ ADP + H + pTYR calcium-transporting ATPase ATP[c] + CA[e] + H2O[c] ⇒ ADP[c] + CA[c] + H[c] + PI[c] Protein degradation (GLU) [c]: ATP + GluGlu + (2) H2O ⇒ ADP + (2) GLU + H + PI Protein degradation (TRP) [c]: ATP + (2) H2O + TrpTrp ⇒ ADP + H + PI + (2) TRP

Metadata
Created	2012-10-01 15:06:49
Last updated	2012-10-01 15:11:53


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