diadenylate_cyclase – diadenylate cyclase

Name
WID diadenylate_cyclase View in model
Name diadenylate cyclase View in model
 
Classification
Type chemical View in model
 
Reaction
Stoichiometry [c]: (2) ATPc_di_AMP + (2) PPI View in model
 
Catalysis
Enzyme MG_105_OCTAMER [c] View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
 
Associations
Process Process_Metabolism View in model
 
Comments
Comments DisA (MG_105) acts as diadenylate cyclase producing c-di-AMP from ATP which may act as a second messenger to regulate the Spo0A sporulation transcriptional regulator [PUB_0195, PUB_0512]. Diadenylate cyclase activity is suppressed when DisA recognizes DNA damage (binds DNA branches formed during homologous recombination repair of strand breaks, base damage, and cross links) [PUB_0195, PUB_0512].
References
  1. Römling U. Great times for small molecules: c-di-AMP, a second messenger candidate in Bacteria and Archaea. Sci Signal 1, pe39 (2008). WholeCell: PUB_0195, PubMed: 18714086

  2. Witte G, Hartung S, Büttner K, Hopfner KP. Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates. Mol Cell 30, 167-78 (2008). WholeCell: PUB_0512, PubMed: 18439896

 
Metadata
Created 2012-10-01 15:08:09
Last updated 2012-10-01 15:15:06