clarithromycin – clarithromycin

Name
WID clarithromycin View in model
Name clarithromycin View in model
Cross references ChEBI: 3732, CAS: 81103-11-9, PubChem: 99313627, KEGG: C06912
 
Classification
Type antibiotic_macrolide View in model
 
Structure
Empirical formula (pH 7.5) H69C38N1O13
SMILES (pH 7.5) CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2C[C@](C)(OC)[C@H](O)[C@@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC
Charge (pH 7.5) 0
Is hydrophobic False View in model
Molecular weight (Da) 747.95 View in model
ΔfG'o (pH 7.5, 25C, I = 0; kJ mol‑1) 1522.20
 
Comments
Comments Binds 23 S rRNA of 50S ribosomal subunit, blocking translocation of aminoacyl-tRNA and polypeptide synthesis [PUB_0847].
References
  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39, D1035-41 (2011). WholeCell: PUB_0847, PubMed: 21059682

 
Metadata
Created 2012-10-01 15:06:52
Last updated 2012-10-01 15:11:58