carbamoylmethyl6dA – N6-carbamoylmethyl-2'-deoxyadenosine

Name
WID carbamoylmethyl6dA View in model
Name N6-carbamoylmethyl-2'-deoxyadenosine View in model
Traditional name 2-({9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl}amino)acetamide
IUPAC name 2-({9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-9H-purin-6-yl}amino)acetamide
Cross references PubChem: 54051794
 
Classification
Type modified_deoxyribonucleoside View in model
 
Structure
Empirical formula (pH 7.5) H16C12N6O4
SMILES (pH 7.5) C1C(C(OC1N2C=NC3=C2N=CN=C3NCC(=O)N)CO)O
Charge (pH 7.5) 0
Is hydrophobic False View in model
Molecular weight (Da) 308.29 View in model
van der Waals volume 
(pH 7.5; Å3 molecule‑1)
255.10
pI 9.21
logP -2.22
logD (pH 7.5) -2.22
 
Function
Reaction participant View in model
 
Comments
Comments formed by E. coli Mu phage mom gene product [PUB_0478]; converts adenosine in consensus sequence [CG]A[GC]NPy [PUB_0478]; modification protects against host nucleases [PUB_0478];
References
  1. Gommers-Ampt JH, Borst P. Hypermodified bases in DNA. FASEB J 9, 1034-42 (1995). WholeCell: PUB_0478, PubMed: 7649402

 
Metadata
Created 2012-10-01 15:06:51
Last updated 2012-10-01 15:11:56