UVB_radiation – UV-B radiation (4 eV)

Name
WID UVB_radiation View in model
Name UV-B radiation (4 eV) View in model
 
Value
Value
0.0 (W/m^2)
View in model
 
Function
Reaction participant View in model
 
Comments
Comments UV-B radiation has wavelengths in the range 280-315 nm, or equivalently energy in the range 3.94–4.43 eV [PUB_0480]. UV-B radiation causes a variety of DNA damage including:
  • cyclopyrimidine dimers (75%, [PUB_0491])
  • 6,4 pyrimidine-pyrimidone photoproducts (25%, [PUB_0491]), which are rapidly converted to [PUB_0491]
  • 6,4 pyrimidine-pyrimidone dewar photoproducts
  • Photoadducts, photohydration, photooxidation (3-4%, [PUB_0492])
Mitchell et al determined that the total rate of DNA lesions caused by 300-315 nm UV-B radiation is 0.3 / 108 DA / (J/m2) [PUB_0480]. UV-B radiation flux depends strongly on latitude. Peeters et al report 0.25 W/m2 UV-B at noon at SF-Bay, CA latitude [PUB_0489]. Clingen et al report 2-9 W/m2 in London, England at 12-4pm [PUB_0491]. UV-B radiation is attenuated by skin and only penetrates ~200 μm [PUB_0776].
References
  1. Clingen PH, Arlett CF, Roza L, Mori T, Nikaido O, Green MH. Induction of cyclobutane pyrimidine dimers, pyrimidine(6-4)pyrimidone photoproducts, and Dewar valence isomers by natural sunlight in normal human mononuclear cells. Cancer Res 55, 2245-8 (1995). WholeCell: PUB_0491, PubMed: 7757971

  2. Kufe DW, Frei E, Holland JF. Cancer medicine-6 review. BC Decker Inc Ch 20 (2003). WholeCell: PUB_0492, ISBN: 9781550092219, URL: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cmed6

  3. Mitchell DL, Jen J, Cleaver JE. Sequence specificity of cyclobutane pyrimidine dimers in DNA treated with solar (ultraviolet B) radiation. Nucleic Acids Res 20, 225-9 (1992). WholeCell: PUB_0480, PubMed: 1311069

  4. Peeters P, Müller JF, Simon PC, Celarier E, Herman J. Estimation of UV flux at the Earth’s surface using GOME data. Earth Observation Quarterly 58, 39-40 (1998). WholeCell: PUB_0489, URL: http://esapub.esrin.esa.it/eoq/eoq58/eoq58-peeters.pdf

  5. UCSF Department of Dermatology. UV Radiation. (2007). WholeCell: PUB_0776, URL: http://www.dermatology.ucsf.edu/skincancer/General/prevention/UV_Radiation.aspx

 
Metadata
Created 2012-10-01 15:09:13
Last updated 2012-10-01 15:18:29