TranscriptionalRegulation_fur_TU_016 – Transcriptional regulation of TU_016 by fur

Name
WID TranscriptionalRegulation_fur_TU_016
Name Transcriptional regulation of TU_016 by fur
 
Regulation
Transcription unit TU_016 View in model
Transcripton factor MG_236_MONOMER View in model
Binding site 3856939582 MG_032 MG_033
Chromosome: Mgenitalium_Chr_1, Coordinate: 39069 (nt), Length: 13 (nt), Direction: Forward, Sequence:
1
AACCAGTTAATTA
13
View in model
Fold‑change activity
0.780195 (dimensionless)
View in model
 
Comments
Comments Fur transcription factor is activated by iron stress (low iron or iron deficiency), and negatively regulates expression of siderophore biosynthesis and ferri-siderophore uptake genes [PUB_0418, PUB_0419, PUB_0438]. Güell et al reported that Fur controls the expression of several genes in M. pneumoniae [PUB_0418]. We estimated the regulatory effect of Fur on the reported genes using the ratio of gene expression under fur overexpression to that of the average of the control conditions (GC_10-NaCl1.1, GC_10-NaCl1.2, and GC_10-NaCl1.3) [PUB_0418]. Binding site computed by aligning upstream regions (100bp) using MEME. Guell et al used the same procedure for M. pneumoniae, but identified a different motif [PUB_0418]. Binding site has motif GT[TC]TTA[TAC]TTT[TGC]AA[AGT]AA. Site responds to the condition: fur overexpression.
References
  1. Baichoo N, Wang T, Ye R, Helmann JD. Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Mol Microbiol 45, 1613-29 (2002). WholeCell: PUB_0438, PubMed: 12354229

  2. Güell M, van Noort V, Yus E, Chen WH, Leigh-Bell J, Michalodimitrakis K, Yamada T, Arumugam M, Doerks T, Kühner S, Rode M, Suyama M, Schmidt S, Gavin AC, Bork P, Serrano L. Transcriptome complexity in a genome-reduced bacterium. Science 326, 1268-71 (2009). WholeCell: PUB_0418, PubMed: 19965477

  3. Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic Acids Res 36, D93-6 (2008). WholeCell: PUB_0419, PubMed: 17962296, URL: http://dbtbs.hgc.jp/

 
Metadata
Created 2012-10-01 15:09:28
Last updated 2012-10-01 15:18:56