TranscriptionalRegulation_fur_TU_008 – Transcriptional regulation of TU_008 by fur

Name
WID TranscriptionalRegulation_fur_TU_008
Name Transcriptional regulation of TU_008 by fur
 
Regulation
Transcription unit TU_008 View in model
Transcripton factor MG_236_MONOMER View in model
Binding site 1504116054 MG471 MG472 MG_013 MG_014
Chromosome: Mgenitalium_Chr_1, Coordinate: 15541 (nt), Length: 13 (nt), Direction: Forward, Sequence:
1
AAACAGCTAATTT
13
View in model
Affinity
10.0 (nM)
View in model
Fold‑change activity
0.2 (dimensionless)
View in model
 
Comments
Comments Fur transcription factor is activated by iron stress (low iron or iron deficiency), and negatively regulates expression of siderophore biosynthesis and ferri-siderophore uptake genes [PUB_0418, PUB_0419, PUB_0438]. Fur transcriptional regulatory activity inferred from B. subtilis [PUB_0438 table 2, PUB_0419]. Binding site computed by aligning upstream regions (100bp) using MEME. Guell et al used the same procedure for M. pneumoniae, but identified a different motif [PUB_0418]. Binding site has motif TGA[TA]AAT[GC]ATT[AT]TCA[AT]T. Site responds to the condition: 0.1 um FeCl3.
References
  1. Baichoo N, Wang T, Ye R, Helmann JD. Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon. Mol Microbiol 45, 1613-29 (2002). WholeCell: PUB_0438, PubMed: 12354229

  2. Güell M, van Noort V, Yus E, Chen WH, Leigh-Bell J, Michalodimitrakis K, Yamada T, Arumugam M, Doerks T, Kühner S, Rode M, Suyama M, Schmidt S, Gavin AC, Bork P, Serrano L. Transcriptome complexity in a genome-reduced bacterium. Science 326, 1268-71 (2009). WholeCell: PUB_0418, PubMed: 19965477

  3. Sierro N, Makita Y, de Hoon M, Nakai K. DBTBS: a database of transcriptional regulation in Bacillus subtilis containing upstream intergenic conservation information. Nucleic Acids Res 36, D93-6 (2008). WholeCell: PUB_0419, PubMed: 17962296, URL: http://dbtbs.hgc.jp/

 
Metadata
Created 2012-10-01 15:09:28
Last updated 2012-10-01 15:18:56