TX_MGTA_ZN – zinc-transporting ATPase

Name
WID TX_MGTA_ZN View in model
Name zinc-transporting ATPase View in model
Cross references EC: 3.6.3.5, BioCyc: 3.6.3.5-RXN, BiGG: ZNabcpp
 
Classification
Type transport View in model
 
Reaction
Stoichiometry ATP[c] + H2O[c] + ZN[e] ⇒ ADP[c] + H[c] + PI[c] + ZN[c] View in model
 
Catalysis
Enzyme MG_071_MONOMER [m] View in model
 
Energetics
Is spontaneous (pH 7.5, 25C, I = 0) False View in model
ΔG (pH 7.5, 25C, I = 0; kJ mol‑1) -6.70
Keq
68080.0948756 ()
 
Associations
Process Process_Metabolism View in model
 
Comments
Comments inorganic cation transport ATPase [PUB_0110]; possibly transports calcium [PUB_096,PUB_0211]; Flavobacterium odoratum p-type calcium atpase is homologous to eukaryotic sarcoplasmic reticulum p-type calcium atpase [PUB_0213]; sacroplasmic calcium p-type atpase may be catalytically active as a monomer [PUB_0214]. Gambel et al observed MgtA kinetic rate of 10 nmol/min mg protein [PUB_0212].
References
  1. Carafoli E, Brini M. Calcium pumps: structural basis for and mechanism of calcium transmembrane transport. Curr Opin Chem Biol 4, 152-61 (2000). WholeCell: PUB_0214, PubMed: 10742184

  2. Chen J, Anderson JB, DeWeese-Scott C, Fedorova ND, Geer LY, He S, Hurwitz DI, Jackson JD, Jacobs AR, Lanczycki CJ, Liebert CA, Liu C, Madej T, Marchler-Bauer A, Marchler GH, Mazumder R, Nikolskaya AN, Rao BS, Panchenko AR, Shoemaker BA, Simonyan V, Song JS, Thiessen PA, Vasudevan S, Wang Y, Yamashita RA, Yin JJ, Bryant SH. MMDB: Entrez's 3D-structure database. Nucleic Acids Res 31, 474-7 (2003). WholeCell: PUB_0110, PubMed: 12520055, URL: http://www.ncbi.nlm.nih.gov/Structure/

  3. Gambel AM, Desrosiers MG, Menick DR. Characterization of a P-type Ca(2+)-ATPase from Flavobacterium odoratum. J Biol Chem 267, 15923-31 (1992). WholeCell: PUB_0212, PubMed: 1386366

  4. Norris V, Grant S, Freestone P, Canvin J, Sheikh FN, Toth I, Trinei M, Modha K, Norman RI. Calcium signalling in bacteria. J Bacteriol 178, 3677-82 (1996). WholeCell: PUB_0213, PubMed: 8682765

  5. Ren Q, Paulsen IT. Large-scale comparative genomic analyses of cytoplasmic membrane transport systems in prokaryotes. J Mol Microbiol Biotechnol 12, 165-79 (2007). WholeCell: PUB_0211, PubMed: 17587866, URL: http://www.membranetransport.org/

 
Metadata
Created 2012-10-01 15:09:06
Last updated 2012-10-01 15:18:07