RIBOSOME_50S – 50S ribosomal subunit

Name
WID RIBOSOME_50S View in model
Name 50S ribosomal subunit View in model
Cross references PDB: 1NKW
 
Structure
Biosynthesis [c]: MGrrnA23S + MGrrnA5S + MG_081_MONOMER + MG_082_MONOMER + MG_093_MONOMER + MG_151_MONOMER + MG_152_MONOMER + MG_153_MONOMER + MG_154_MONOMER + MG_156_MONOMER + MG_158_MONOMER + MG_159_MONOMER + MG_161_MONOMER + MG_162_MONOMER + MG_163_MONOMER + MG_166_MONOMER + MG_167_MONOMER + MG_169_MONOMER + MG_174_MONOMER + MG_178_MONOMER + MG_197_MONOMER + MG_198_MONOMER + MG_232_MONOMER + MG_234_MONOMER + MG_257_MONOMER + MG_325_MONOMER + MG_361_MONOMER + MG_362_MONOMER + MG_363_MONOMER + MG_418_MONOMER + MG_426_MONOMER + MG_444_MONOMER + MG_466_MONOMER + MG_473_MONOMERRIBOSOME_50S View in model
No. subunits 34
Empirical formula (pH 7.5) H66044C48754N18215O25566P2838S128
Molecular weight (pH 7.5; Da) 1408316.08 View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)
-29138560.00
Half life (OD (600 nm) = 0.3, 
M9 media, 36C; min)
1200.00 View in model
 
Synthesis
Formation process Process_RibosomeAssembly View in model
Localization c
 
Regulation
Regulatory rule !azithromycin & !chloramphenicol & !clarithromycin & !clindamycin & !erythromycin & !lincomycin & !pristinamycin View in model
 
Function
Complex subunit View in model
 
Comments
Comments Regulation: Macrolide, lincosamide, and chloramphenicol antibiotics inhibit 50S ribosomal subunits [PUB_0847].
References
  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res 39, D1035-41 (2011). WholeCell: PUB_0847, PubMed: 21059682

 
Metadata
Created 2012-10-01 15:07:43
Last updated 2012-10-01 15:14:19