Process_Replication – Replication

Name
WID Process_Replication
Name Replication
 
Implementation
Initialization order 22 View in model
 
Reactions
Chemical reactions View in model
Complex formation reactions View in model
 
Parameters
Parameters View in model
 
Comments
Comments Summary This function polymerizes DNA bidirectionally from oriC to terC of both the leading and lagging strands. It models the locations of all of the replisome machinery proteins, and applies limits to replication (energy, coordination of strands, availibility of ligases, SSBs,...). References Mirkin, E.V., Mirkin, S.M. (2007). Replication fork stalling at natural impediments. Microbiology and molecular biology reviews 71: 13-35. Mirkin, E.V., Mirkin, S.M. (2005). Mechanisms of Transcription-replication collisions in bacteria. molecular and cellular biology 25: 888-895. Mirkin, E.V., Roa, D.C., Nudler, E., Mirkin, S.M. (2006). Transcription regulatory elements are punctuation marks for dna replication. PNAS 103: 7276-7281. Miyata, M. Cell Division. Molecular biology and pathogenicity of mycoplasmas. Razin, S., Herrmann, R. Kluwer Academic/Plenum Publishers, 2002. 117-130. Rudolph, C.J., Dhillon, P., Moore, T., Lloyd, R.G. (2007). Avoiding and resolving conflicts between DNA replication and transcription. DNA Repair 6: 981-993. McGlynn, P., Guy, C.P. (2008). Replication forks blocked by protein-DNA complexes have limited stability in vitro. J. Mol. Biol. 381: 249-255.
 
Metadata
Created 2012-10-01 15:07:35
Last updated 2012-10-01 15:14:00