Process_Cytokinesis – Cytokinesis

Name
WID Process_Cytokinesis
Name Cytokinesis
 
Implementation
Initialization order 16 View in model
 
Reactions
Chemical reactions FtsZ ring contraction
[c]: (18) H2O + (2) MG_224_9MER_GTP ⇒ (18) H + (2) MG_224_9MER_GDP + (18) PI
View in model
 
Parameters
Parameters View in model
 
Comments
Comments M. genitalium divide by binary fission. First, once the cell reaches a critical volume, the chromosomes are segregated by several enzymes including Smc, ScpA, and ScpB. Second, the protein FtsZ binds GTP, polymerizes, and forms rings around the cell's longitudinal midpoint. Next, FtsZ hydrolyzes GTP, causing the contraction of each FtsZ monomer and the cell membrane. Finally, the FtsZ forms successive smaller rings, resulting in septation. Simulation of binary fission will be begin when the cell reaches a critical volume, as estimated by the total cellular mass and experimentally measured density. Chromosome segregation will be modeled by a set of Boolean rules. FtsZ polymerization will be modeled according to the iterative pinching model described by Li et al, 2007 [PUB_0611]. Finally, the cytoplasm contents will be stochastically sorted between the two daughter cells.
References
  1. Li Z, Trimble MJ, Brun YV, Jensen GJ. The structure of FtsZ filaments in vivo suggests a force-generating role in cell division. EMBO J 26, 4694-708 (2007). WholeCell: PUB_0611, PubMed: 17948052

 
Metadata
Created 2012-10-01 15:07:35
Last updated 2012-10-01 15:13:59