||Authors present a history of the study of mycoplasmas
1898: bovine plueropneumoniae cultivated, mycoplasmas believed to be viruses
1950's -1960's: many believed mycoplasmas were bacterial L-forms or bacteria which had lost their cell walls
1960's-1970's: ultrastructure studied. Morowitz and Wallace argue that Mycoplasma are the most primitive organisms and should be placed at the root of the phylogenetic tree. Neimark proposed that Mycoplasmas originated from walled bacteria. rRNA sequence data confirms Neimark's hypothesis. Maniloff posits that Mycoplasmas arose from the Streptococcus branch 600 million years ago.
Bredt et al show that Mycoplasma replicates by binary fission
Mammalian and insect mollicutes shown to be surface and intracellular parasites
1980's: Morowitz proposes large-scale sequencing effort, but a collaboration never took off; various groups worked independently to map the Mycoplasma genome
1995: TIGR publishes complete sequence of M. genitalium. Herrmann publishes M. pneumoniae sequence shortly thereafter.
1990's: comparatively genomics began, several groups got interested in the minimal gene complement
2000's: JVCI synthesizes Mycoplasma genome