Note_DNADamage – DNADamage

Name
WID Note_DNADamage
Name DNADamage
 
Comments
Comments DNA damage was reconstructed from a variety of sources. Kaye and Laby observed the energy distribution of ionizing radiation at >40°N [PUB_0490]: ParticleEnergy (keV)Flux (1/m2/s/sr) e-> 100060 e-> 1000028 e-> 2000020 e-> 1000006 e-> 2000003 e-> 5000001 e-> 10000000.38 e-> 20000000.12 e-> 50000000.02 proton> 10002.1 proton> 100002.1 proton> 200002.1 proton> 1000001.9 proton> 2000001.5 proton> 5000000.9 proton> 10000000.51 proton> 20000000.25 proton> 50000000.077 proton> 100000000.025 proton> 200000000.008 proton> 500000000.0016 proton> 1000000000.00043 proton> 2000000000.00011 proton> 5000000000.00002 Using a track structure model Nikjoo et al calculated the amount of DNA damage caused by electrons of various energies [PUB_0486]: Energy (keV) Ionizations & Excitations Ionizations 0.112.75 0.336.815.5 0.5128.225.5 1249.949.9 1.5373.272.7 4.51121.2200.4 Using a track structure model Nikjoo et al calculated the amount of DNA damage caused by ionizing radiation of various energies [PUB_0485]: ParticleEnergy (keV)LET (keV)No BreakSSBSSB+ 2SSBDSBDSB+DSB++Total Electron0.366.426.53.30.42.40.90.0999.99 Electron1.570.524.32.40.41.70.60.0799.97 Electron4.571.424.12.30.31.50.50.04100.14 Proton0.358.555.226.57.11.54.83.61.3100 Proton0.541.560.426.35.41.13.92.30.6100 Proton0.7533.163.525.84.613.31.60.3100.1 Proton125.466.624.83.70.72.71.10.399.9 Proton215.570.623.52.60.520.70.1100 Proton49.273.621.72.10.51.60.50.1100.1 a-particle216851.323724.86.25.7100 a-particle312951.424.47.625.35.73.7100.1 a-particle410556.724.96.51.54.34.12.2100.2 a-particle679.258.521.55.11.23.52.71.393.8 a-particle864.461.825.15.113.92.40.7100 a-particle1034.864.324.84.413.21.90.4100 Pomplun et al cataloged double strand break yields of ionizing radiation (Gy-1 dalton-1 10-12) [PUB_0483]: RadiationExperimentCalculated 60CO y-rays4.26.1 140 kV X-rays11.76.2 A1K X-rays9.310.2 CK X-rays1614.6 241Am a-particles1520.7 241Am a-particles19.120.7 He ions, 33 keV/µm6.811 He ions, 50 keV/µm9.414.5 He ions, 66 keV/µm8.616 He ions, 70 keV/µm1318 He ions, 100 keV/µm18.320 He ions, 160 keV/µm23.221 C ions 360 keV/µm13.120 Michalik and Frankenberg catalogued the fraction per absorbed dose in percentage of simple and complex DSB for different initial electron energies [PUB_0481]. Values are obtained on the assumption that simple DSB are exclusively induced by energy transfers
References
  1. Kaye GWC, Laby TH. Tables of physical and chemical constants. Longman Sc & Tech 2.7.7 (1995). WholeCell: PUB_0490, ISBN: 9780582226296, URL: http://www.kayelaby.npl.co.uk/

  2. Michalik V, Frankenberg D. Simple and complex double-strand breaks induced by electrons. Int J Radiat Biol 66, 467-70 (1994). WholeCell: PUB_0481, PubMed: 7983433

  3. Nikjoo H, O'Neill P, Goodhead DT, Terrissol M. Computational modelling of low-energy electron-induced DNA damage by early physical and chemical events. Int J Radiat Biol 71, 467-83 (1997). WholeCell: PUB_0486, PubMed: 9191891

  4. Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat Res 156, 577-83 (2001). WholeCell: PUB_0485, PubMed: 11604075

  5. Pomplun E, Terrissol M. Low-energy electrons inside active DNA models: a tool to elucidate the radiation action mechanisms. Radiat Environ Biophys 33, 279-92 (1994). WholeCell: PUB_0483, PubMed: 7708902

 
Metadata
Created 2012-10-01 15:07:34
Last updated 2012-10-01 15:13:57