MG_423 – metallo-beta-lactamase superfamily protein

Name
WID MG_423 View in model
Name metallo-beta-lactamase superfamily protein View in model
Protein product MG_423_MONOMER
Cross references GenBank: AAC71647.1, BioCyc: MG_423, CMR: MG_423, SwissProt: P47662
Homologs
 
Classification
Type mRNA View in model
 
Structure
Structure 527032533718 MG_422 MG_423 MG_425 MG_427 View in model
Sequence Chromosome: Mgenitalium_Chr_1, Coordinate: 529532 (nt), Length: 1686 (nt), Direction: Reverse, G/C content: 29.6%, Sequence:
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ATGGCTAAGATTAAATTCTTTGCGCTCGGCGGTCAAGATGAACGTGGTAA
AAATTGCTATGTGCTTGAAATTGACAATGATGTGTTTATCTTTAATGTTG
GTAGCTTAACACCAACAACAGCAGTTTTAGGTGTTAAAAAAATTATTCCT
GATTTTAGTTGAATTCAAGAAAATCAAGCAAGAGTTAAAGGTATTTTTAT
AGGTAATGCCATTACTGAAAACTTAGGATCATTAGAATTTTTGTTCCATA
CAGTAGGATTTTTTCCTATTTACACAAGTTCAATAGGCGCTTCTATAATT
AAAAGCAAAATTAATGAAAACAAACTTAATATTGCACGTGATAAATTGGA
AATTCATGAATTAAAACCACTTGAAACAATCGAAATTTCTAATCATTCTA
TTACCCCTTTTAAAGTATCAAGTTCTTTACCATCATCATTTGGATTTGCT
TTAAATACTGATAATGGTTACATCGTTTTTATTGATGATTTCATTGTTTT
AAATGATAAGAACATTGCTTTTGAAAATCAACTAAATCAAATTATCCCTA
AACTTTCTGACAATACATTGTTATTAATAACAGGAGTTGGTTTAGTTGGT
AGAAACAGTGGTTTTACAACACCTAAACACAAGTCATTAGAACAGTTAAA
CAGGATCATAACTCCAGCCAAAGGCAGAATATTTGTAGCTTGTTATGATT
CAAATGCTTACAGTGTTATGACTCTTGCCCAGATTGCAAGGATGCAAAAT
CGTCCTTTTATTATCTATTCACAATCATTTGTGCATCTCTTTAACACAAT
TGTGCGTCAAAAATTGTTTAATAACACGCATTTAAATACCATTTCTATTG
AGGAGATTAACAATTCAACCAACAGTATTGTTGTTCTCACCTCACCACCT
GATAAGTTGTATGCTAAATTATTCAAAATTGGAATGAACGAAGATGAAAG
AATTCGTTATCGTAAGAGTGATACTTTTATCTTTATGACTCCTAAAGTTG
CTGGCTATGAAGAGATAGAAGCACAAATCCTTGATGATATTGCACGTAAT
GAAGTTAGTTATTACAACTTAGGTAGAGAAATCCTTTCTATCCAAGCAAG
TGATGAAGATATGAAGTTTTTAGTTAGTTCTTTAAAACCAAAATATATTA
TTCCAACTGGTGGACTTTATAGGGATTTTATAAACTTCACAATGGTTTTA
AAACAAGCTGGCGCTGAGCAAAATCAAATCTTAATTCTTTTTAACGGTGA
AGTTTTAACTATTGAAAACAAAAAACTAGATAGCAAAAAAAATGAATTGA
AATTAAATCCTAAGTGTGTTGATTCTGCTGGATTACAAGAAATTGGAGCT
AGCATTATGTTTGAACGTGATCAAATGTCAGAATCTGGAGTTGTGATCAT
AATCATTTATTTTGATCAAAAAAAGAGTGAATTCTTAAATGAGATAACTT
ATTCTTTTTTAGGAGTATCTTTAGATGTACCAGAAAAAGATAAACTAAAA
ACAAAAATGGAAGAATTAATTAAAAAACAAATTAATGATATTAAGGATTT
CACCACGATTAAAAAACGAATAGGTAAAGAAATTTCAAAAGAATTGAAGG
TTTCTATTAAACGAGCAGTAATGAATTTATTCACCAAGATGACATCAAAA
GCACCCTTAATTCTTTCAACTATTATTTCTATTTAA
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1686
View in model
Transcription unit TU_301 View in model
Empirical formula (pH 7.5) H17981C16294N6732O11748P1686
Molecular weight (pH 7.5; Da) 548301.28 View in model
 
Functional genomics
Is essential
Yes (Show evidence)
View in model
Relative expression
0.851454 (dimensionless) (Show evidence)
View in model
Half life
4.425 (min) (Show evidence)
View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)
17553500
pI 4.01
 
Comments
Comments beta-CASP family [PUB_0163]; lacks part of all the conserved amino acids that should be involved in the enzymatic function [PUB_0163];
References
  1. Bernstein JA, Khodursky AB, Lin PH, Lin-Chao S, Cohen SN. Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A 99, 9697-702 (2002). WholeCell: PUB_0602, PubMed: 12119387

  2. Callebaut I, Moshous D, Mornon JP, de Villartay JP. Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family. Nucleic Acids Res 30, 3592-601 (2002). WholeCell: PUB_0163, PubMed: 12177301

  3. Glass JI, Assad-Garcia N, Alperovich N, Yooseph S, Lewis MR, Maruf M, Hutchison CA 3rd, Smith HO, Venter JC. Essential genes of a minimal bacterium. Proc Natl Acad Sci U S A 103, 425-30 (2006). WholeCell: PUB_0193, PubMed: 16407165

  4. Weiner J 3rd, Zimmerman CU, Göhlmann HW, Herrmann R. Transcription profiles of the bacterium Mycoplasma pneumoniae grown at different temperatures. Nucleic Acids Res 31, 6306-20 (2003). WholeCell: PUB_0569, PubMed: 14576319

 
Metadata
Created 2012-10-01 15:07:28
Last updated 2012-10-01 15:13:41