MG_312 – high molecular weight cytadherence accessory protein 1

Name
WID MG_312 View in model
Name high molecular weight cytadherence accessory protein 1 View in model
Symbol hmw1
Protein product MG_312_MONOMER
Cross references GenBank: AAC71534.1, CMR: MG_312, BioCyc: MG_312, SwissProt: Q49413
Homologs
 
Classification
Type mRNA View in model
 
Structure
Structure 385416393836 MG_309 MG_310 MG_311 MG_312 MG_313 MG_314 View in model
Sequence Chromosome: Mgenitalium_Chr_1, Coordinate: 387916 (nt), Length: 3420 (nt), Direction: Reverse, G/C content: 32.3%, Sequence:
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3401
ATGGCTAAAAACAAGCAATCGGTTTTTGAAGAAAAAAACTATACCCAAAC
CGAACCTGAAAACATTTTTGGTGATCTTTATGATGGTAAATCCACTGTTG
AAGAAGACCCTAATATTAAGGTAGCATATGATGCTGATGGTAATGGCTAT
TATATAGCTTTTAACAAAGAAACAGGGGTTTACTATGATCCTTATGGAGA
TACTGAATATGATATCTCCCAACTCTTTGATGAAAATGGGAATCCGTTTG
TTTTTGATGAAAAGCAAGAAGAGAATGATTATTTAAAGTATGTTGGTAAC
CCTGACTATGGTTCTTATGATGAAAATGGTGAGTGGGTTTGATCTGGTTA
CTTTGAAAATGACCAGTGGATCTCCACTAAAGAATCTCAACCAACTGATG
AAAACTATGGTTTTGACAGTGATTTACCACCAGAAGTAAAACAACCTGAA
TCAGTTGAAGATAACTATGGTTTTGATAACGATTTACCACCAGAAGTAAA
ACAACCTGAATCAGTTGAAGATAACTATGGTTTTGATAACGACCTACCAC
CAGAAGTAAAACAACCTGAATCAGTTGTTGACCAGCCTTCTTCAGATGAT
TATTTTGCAAAACAACCAACTGATGAAAACTATGGTTTTGATAACGACCT
ACCACCAGAAGTAAAACAACCTGAATCAGTTGTTGACCAACCTTCTTCAG
ATGATCATTTTGCAAAACAACCTGAATCAACAACTGATAGCTACAGCTTT
GACAGTGATTTACCTCAACCAACCCTTGACCAACCTTCTTTAGATGATCA
TGTTCAGTACAACTTTGATCACCATGAAGAGCTCAAACCAGTTGCTGAAG
AACAAAATAATTATCAAGTTGGATTTGATCAAGTTCAAGCTAATCTTGAT
AATAATGAGGAAATACAACCAACTGCTGAAAAAAAAGTAACTACTGATTT
TGAAAGTAAACAAGCCCAAGTAGTTGATAGTTACCAATTACCAATTGATA
CAGATCAACAAGACCAAACAACTTTTTCTTCTTCATTTGAAACTCAACCA
ACAGTTGAGCAGTTTGATCAAGTAAATAGCGAAGTTAACGATCAATTCAA
ACCTGAAATAACTAAGGAGCCAGTTTTAGAAAGTAGTTTCAATAAACAAG
ATGTAGTTGAAACTAGTGACTTAAATTCTGAATCTAATCTTTACTCTGAA
AACAACAAAGATGCAACTAACAATGATTCATTAAATTCTGAATTCATTCA
ACTTAATAGTAATAGTGAAACTGCATCTGATGATGTGCATTATGAAAGTA
AATCTGAACCAATTCATGACTATAAATTTGGGAGTGATTTATCTCAATCA
AACAGCAATAATTCGTTAGAGTCTGAACCTGTTAAGTTTAATAGTGAAAC
TGCACCTGATGCACACTTTGAAAGTCAATCTGAACCAGTTGATCAAGTTC
AATACGACATTTATCAAAATGAAGAGCTAAAACCAACTCTTGACCAGCCT
TCTTCAGATGATTATTTTGCAAAACAACCAACTGATGAAAACTATGGTTT
TGATAACGACCTACCACCAGAAGTAAAACAACCTGAATCAGTTGTTGACC
AGCCTTCTTCAGATGATCATTTTGCAAAACAACCTGAATCAACAACTGAT
AGCTACAGCTTTGACAGTGATTTACCTCAACCAACCCTTGACCAACCTTC
TTTAGATGATCATGTTCAGTACAACTTTGATCACCATGAAGAGCTCAAAC
CAGTTGCTGAAGAACAAAATAATTATCAAGTTGGATTTGATCAAGTTCAA
GCTAATCTTGATAATAATGAGGAAATACAACCAACTGCTGAAAAAGAAGT
AACTACTGATTTTGAAAGTAAACAAGCCCAAGTAGTTGATAGTTACCAAT
TACCAATTGATACAGATCAACAAGACCAAACAACTTTTTCTTCTTCATTT
GAAACTCAACCAACAGTTGAGCAGTTTGATCAAGTAAATAGCGAAGTTAA
CGATCAATTCAAACCTGAAATAACTAAGGAGCCAGTTTTAGAAAGTAGTT
TCAATAAACAAGATGTAGTTGAAACTAGTAACTACACTAATAATTTACAG
AAATTTGATATTCAGTCTGATAATAAGATAACTATCACTACCAAAAAAAG
TTCACCCCAAATCCCTACAACTTTACCTATTAGTTTTGTATCCAACCGTA
TTGAATATAAACCAGTTGAAACTTTAGCTTTAGATAATAAAGAAAGTCAG
CAAGAACAAATTACCATTAATTCCATAACTGAAGATTCCAAAACACTTGC
AAAAACATTATCTGTCCAATTGCAACAAATTAATAGCTTAAATAATCAAT
CAATTGTTACTAGTGAATCAGTAAGACTCGATAAAAAAGATGATCAACTA
ACTATCAATACTGTTAATAGCGAAGACCAACAACCTAAAATTGAAGTTTT
TGTCAAAGCAAAAGAACCTGTTGAAGAACACTCAATTACTCAAAATAAGC
AATCGGTTGAAGATAAAAGTGAACTTGATAATTTCAATAAAAAATCAGAT
CTTTACAAGATTATTAGTGAATTGAAACGTGGTGAATTAAACCCTACAAT
TAACTTTGATGCAATCTTTCAAATGAATGATTATCAGATGTCTGTTAAAC
AATCATTTATCCATCTCAATGATTTTGTTACCAACTATAAGAACCAAATT
AGTGAACGTTACTTAATAATTAAAAAGGAATTACAAAGTGAACTTTCCCG
TTTAATTGATCAAAATGAGAACCTTAACGTTCAATTTAATAACGCTAAGA
ATCTAACAACACTTCAAAAAGAAGAAATGATCAGATCATTAGCTAGTGAT
TTTGCTATTGCTTACAAACCAAGTAATAGTTATGAACAACTGCAAAAATC
TGGAGAAATTATGCGTCATGTTCAACGTGCTATCACTGAAAATGAAAAGA
AGATAGAAAGCATTCAAGGTAGTTTAAAACAACTTAAAACTGTTTATAAC
TCTTGTTGTGAAACTATTATGAACAACATTAATAAGCTTGATAATACGCT
CCGCTTTGCAAAGAAAGAAAAAGATCCTTTACTTTTAAGCAATTTTGATA
GTGTAACAGATAATGGGTTAGTAGAACCTAATCAGTTAATGGATGATTTA
ATAGATTTTTCCAACACTTTTGATAACATCTCCAATGAACAGTTAGATGA
TTTTATCTATGAAAACATGGATCGTAACATCGATTTTGAATTTGAAGGTT
TTAACAATGATTTTGTTGACATTGATGCCAAAGTAATGGATTCAATGAGT
GCTTTTAGTGTTAATGATTTGGATATAGAAACACTAGTTCCTGATCGTAC
TTCCAATTTCAGTTCATTATTAGATGAAGACTTATTTGAAAGCAGTGGTG
ATTTTAGCCTTGATTATTAA
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3420
View in model
Transcription unit TU_214 View in model
Empirical formula (pH 7.5) H36614C33193N14079O23639P3420
Molecular weight (pH 7.5; Da) 1116914.96 View in model
 
Functional genomics
Is essential
Yes (Show evidence)
View in model
Relative expression
1.96428 (dimensionless) (Show evidence)
View in model
Half life
4.425 (min) (Show evidence)
View in model
Extinction coefficient 
(260 nm, 25C, pH 7.0)
35452400
pI 3.78
 
Comments
Comments required for property function of adhesins, may help localize adhesins to tip organelle, part of the cytoskeleton-like Triton shell [PUB_0088]; high Pro content, low pI, central acidic Pro-rich domain [PUB_0089]; required for gliding [PUB_0091];
References
  1. Balish MF, Krause DC. Mycoplasmas: a distinct cytoskeleton for wall-less bacteria. J Mol Microbiol Biotechnol 11, 244-55 (2006). WholeCell: PUB_0091, PubMed: 16983199

  2. Bernstein JA, Khodursky AB, Lin PH, Lin-Chao S, Cohen SN. Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A 99, 9697-702 (2002). WholeCell: PUB_0602, PubMed: 12119387

  3. Glass JI, Assad-Garcia N, Alperovich N, Yooseph S, Lewis MR, Maruf M, Hutchison CA 3rd, Smith HO, Venter JC. Essential genes of a minimal bacterium. Proc Natl Acad Sci U S A 103, 425-30 (2006). WholeCell: PUB_0193, PubMed: 16407165

  4. Proft T, Hilbert H, Plagens H, Herrmann R. The P200 protein of Mycoplasma pneumoniae shows common features with the cytadherence-associated proteins HMW1 and HMW3. Gene 171, 79-82 (1996). WholeCell: PUB_0089, PubMed: 8675035

  5. Razin S, Jacobs E. Mycoplasma adhesion. J Gen Microbiol 138, 407-22 (1992). WholeCell: PUB_0088, PubMed: 1593256

  6. Weiner J 3rd, Zimmerman CU, Göhlmann HW, Herrmann R. Transcription profiles of the bacterium Mycoplasma pneumoniae grown at different temperatures. Nucleic Acids Res 31, 6306-20 (2003). WholeCell: PUB_0569, PubMed: 14576319

 
Metadata
Created 2012-10-01 15:07:24
Last updated 2012-10-01 15:13:25